ArticleInternational journal of molecular sciences2025
Functional Characterization of the Hephaestin Variant D568H Provides Novel Mechanistic Insights on Iron-Dependent Asbestos-Induced Carcinogenesis.
Paola Zacchi, Francesco Longo, Alice Marconato, Matteo Amadei, Maria Carmela Bonaccorsi di Patti, Elisa Avolio, Pengfei Li, Hongkuan Fan, Teresa D Tetley, Giuliano Zabucchi and 1 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Francesco LongoDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Alice MarconatoDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Matteo AmadeiDepartment of Biochemical Sciences, Sapienza University of Roma, 00185 Rome, Italy.
Maria Carmela Bonaccorsi di PattiDepartment of Biochemical Sciences, Sapienza University of Roma, 00185 Rome, Italy.ORCID 0000-0002-4794-7037 Elisa AvolioBristol Medical School, Translational Health Sciences, University of Bristol, Level 7 Bristol Royal Infirmary, Bristol BS2 8HW, UK.ORCID 0000-0003-4801-8480 Pengfei LiDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Hongkuan FanDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0002-9441-9405 Teresa D TetleyNational Heart and Lung Institute, Imperial College London, Exhibition Road, London SW7 0HF, UK.
Giuliano ZabucchiDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Violetta BorelliDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Funding
The Role of Pericytes in Brain Hypoperfusion in Alzheimer's Disease DevelopmentR01AG081807 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Hongkuan Fan · 2023 to 2026
$2.5MThe Role of Pericytes in the Vascular Dysfunction of SepsisR35GM149203 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Hongkuan Fan · 2023 to 2026
$1.8MAssociazione Esposti Amianto (AEA) Monfalcone (Gorizia) Liberal donationInstruct-ERIC (PID 27484) Internship award (APPID 3087)Lega Italiana per la Lotta contro i Tumori (LILT)- Associazione Provinciale Isontina Monfalcone (Gorizia) Liberal donationNIA NIH HHS R01 AG081807NIGMS NIH HHS R35 GM149203
6 · The paper itselfAbstract
A local disruption of iron homeostasis leading to oxidative stress is considered one of the main mechanisms of asbestos-related genotoxicity. Another aspect contributing to the risk of developing pathological consequences upon asbestos exposure is individual genetic factors. In a previous study, we identified a coding SNP in the hephaestin gene (
Indexed as
AsbestosCarcinogenesisIronLung NeoplasmsMembrane ProteinsAnimalsCation Transport ProteinsCeruloplasminFerroportinHumansAsbestosCation Transport ProteinsCeruloplasminFerroportinHEPH protein, humanIronMembrane Proteinsasbestoshephaestinironlung cancermesotheliomapericytessingle nucleotide polymorphism
Identifiers
PMID40141249
PMCPMC11941830
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