Evidence map›Paper›PMID 40141218›Full record

ArticleInternational journal of molecular sciences2025

Antitumor Activity of Radiation Therapy Combined with Checkpoint Kinase Inhibition in SHH/

Zuzana Kuchařová, Annegret Glasow, Rolf-Dieter Kortmann, Ina Patties

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zuzana KuchařováDepartment of Radiation Oncology, Leipzig University, Stephanstraße 9A, 04103 Leipzig, Germany.ORCID 0009-0002-7196-3149
Annegret GlasowDepartment of Radiation Oncology, Leipzig University, Stephanstraße 9A, 04103 Leipzig, Germany.
Rolf-Dieter KortmannDepartment of Radiation Oncology, Leipzig University, Stephanstraße 9A, 04103 Leipzig, Germany.
Ina PattiesDepartment of Radiation Oncology, Leipzig University, Stephanstraße 9A, 04103 Leipzig, Germany.ORCID 0000-0001-6101-3145

Funding

Mitteldeutsche Kinderkrebsforschung n.a.Open Access Publishing Fund of Leipzig University n.a.
6 · The paper itself

Abstract

Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Current therapy results in a poor prognosis for high-risk SHH/

Indexed as

Cerebellar NeoplasmsHedgehog ProteinsMedulloblastomaProtein Kinase InhibitorsTumor Suppressor Protein p53AnimalsApoptosisCell Line, TumorCell ProliferationCheckpoint Kinase 1Checkpoint Kinase 2DNA DamageHumansMiceMutationPyrazinesCheckpoint Kinase 1Checkpoint Kinase 2CHEK1 protein, humanHedgehog ProteinsprexasertibProtein Kinase InhibitorsPyrazinesPyrazolesPyrimidinesSHH protein, humanTP53 protein, humanTumor Suppressor Protein p53cell cycle checkpoint inhibitioncheckpoint kinase 1DNA damagemedulloblastomaorthotopic mouse modelprexasertibradiation therapySAR-020106

Identifiers

PMID40141218
PMCPMC11942233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.