Evidence map›Paper›PMID 40141159›Full record

ArticleInternational journal of molecular sciences2025

Virginia Valentini, Raffaella Santi, Valentina Silvestri, Calogero Saieva, Giandomenico Roviello, Andrea Amorosi, Eva Compérat, Laura Ottini, Gabriella Nesi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Virginia ValentiniDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-3393-7185
Raffaella SantiDepartment of Health Sciences, Section of Anatomic Pathology, University of Florence, 50139 Florence, Italy.ORCID 0009-0005-5317-7533
Valentina SilvestriDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-0712-9379
Calogero SaievaRisk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research and Clinical Network (ISPRO), 50134 Florence, Italy.ORCID 0000-0002-0117-1608
Giandomenico RovielloDepartment of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, 50139 Florence, Italy.ORCID 0000-0001-5504-8237
Andrea AmorosiDepartment of Health Sciences, "Magna Graecia" University of Catanzaro, 88100 Catanzaro, Italy.
Eva CompératDepartment of Pathology, Medical University of Vienna, 1090 Vienna, Austria.
Laura OttiniDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-8030-0449
Gabriella NesiDepartment of Health Sciences, Section of Anatomic Pathology, University of Florence, 50139 Florence, Italy.ORCID 0000-0002-2614-944X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic changes have been reported to promote the development and progression of prostate cancer (PCa). Compared to normal prostate tissue, tumor samples from patients treated with androgen-deprivation therapy (ADT) show the hypermethylation of genes primarily implicated in PCa progression. A series of 90 radical prostatectomies was retrospectively analyzed. A total of 46 patients had undergone surgery alone (non-treated) and 44 had received ADT prior to surgery (treated). Promoter methylation analysis of the candidate genes possibly involved in PCa response to ADT (

Indexed as

DNA MethylationEpigenesis, GeneticHyaluronan ReceptorsProstatic NeoplasmsAgedAndrogensDisease ProgressionGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPromoter Regions, GeneticRetrospective StudiesTranscriptional Regulator ERGAndrogensCD44 protein, humanERG protein, humanHyaluronan ReceptorsTranscriptional Regulator ERGandrogen deprivationCD44epigeneticsprostate cancer

Identifiers

PMID40141159
PMCPMC11942495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.