Avasimibe Abolishes the Efficacy of Fluvastatin for the Prevention of Cancer in a Spontaneous Mouse Model of Breast Cancer.

Anjana Bhardwaj, Alexander Koh, Rhea Bhala, Janvi Sandhu, Zhenlin Ju, Leslie Faye Cando, Jing Wang, Isabelle Bedrosian

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anjana BhardwajBreast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0003-4234-0241

Alexander KohBreast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Rhea BhalaBreast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0003-0142-0077

Janvi SandhuBreast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Zhenlin JuDepartment of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Leslie Faye CandoBreast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-6089-9861

Jing WangDepartment of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Isabelle BedrosianBreast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Funding

The University of Texas MD Anderson Cancer Center RCTS# 2023-00062064

6 · The paper itself

Abstract

The cholesterol biosynthesis pathway is upregulated during breast cancer development and progression. Inhibition of the aberrantly upregulated cholesterol pathway by statins reduces breast tumor incidence and burden by 50% in SV40 C3(1) TAg mice, a mouse model of triple negative breast cancer. We hypothesized that fluvastatin's preventive efficacy could be further enhanced by co-targeting the statin-induced restorative feedback pathways that tightly control the cholesterol pathway and are involved in resistance to statins. Acyl-coenzyme A: cholesterol acyltransferase (

Indexed as

Breast NeoplasmsFatty Acids, MonounsaturatedIndolesAnimalsCell Line, TumorCell ProliferationCholesterolDisease Models, AnimalFemaleFluvastatinHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMiceSterol O-AcyltransferaseSterol O-Acyltransferase 2CholesterolFatty Acids, MonounsaturatedFluvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsIndolesSterol O-AcyltransferaseSterol O-Acyltransferase 2avasimibebreast cancerdrug–drug interactionmousepreventionstatinTNBC

Identifiers

PMID40141147

DOI10.3390/ijms26062502

PMCPMC11942263

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.