Evidence map›Paper›PMID 40141113›Full record

ArticleInternational journal of molecular sciences2025

SUMO-G5C23-D208G@ZIF-F: A Novel Immobilized Enzyme with Enhanced Stability and Reusability for Organophosphorus Hydrolysis.

Shunye Wang, Ming Ma, Ziyang Wang, Fengqian Cui, Qiqi Li, Zhuang Liu, Dan Wang, Yanan Zhai, Jing Gao

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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Shunye WangSchool of Pharmacy, Qingdao University, Qingdao 266071, China.
Ming MaBeijing Institute of Pharmacology and Toxicology, State Key Laboratory of National Security Specially Needed Medicines, Beijing 100850, China.
Ziyang WangBeijing Institute of Pharmacology and Toxicology, State Key Laboratory of National Security Specially Needed Medicines, Beijing 100850, China.
Fengqian CuiBeijing Institute of Pharmacology and Toxicology, State Key Laboratory of National Security Specially Needed Medicines, Beijing 100850, China.
Qiqi LiBeijing Institute of Pharmacology and Toxicology, State Key Laboratory of National Security Specially Needed Medicines, Beijing 100850, China.
Zhuang LiuBeijing Institute of Pharmacology and Toxicology, State Key Laboratory of National Security Specially Needed Medicines, Beijing 100850, China.
Dan WangBeijing Institute of Pharmacology and Toxicology, State Key Laboratory of National Security Specially Needed Medicines, Beijing 100850, China.
Yanan ZhaiBeijing Institute of Pharmacology and Toxicology, State Key Laboratory of National Security Specially Needed Medicines, Beijing 100850, China.
Jing GaoBeijing Institute of Pharmacology and Toxicology, State Key Laboratory of National Security Specially Needed Medicines, Beijing 100850, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organophosphorus hydrolase (OPH) is a highly effective bioscavenger for detoxifying hazardous organophosphorus compounds. However, its practical application is hindered by low yield and poor stability. In this study, we employed Small Ubiquitin-like Modifier (SUMO) fusion expression to enhance the solubility of the OPH mutant G5C23-D208G and, for the first time, immobilized the enzyme on a zeolitic imidazolate framework-F (ZIF-F) carrier to improve its stability. The SUMO-G5C23-D208G fusion protein was successfully expressed in

Indexed as

AryldialkylphosphataseEnzymes, ImmobilizedOrganophosphorus CompoundsZeolitesEnzyme StabilityEscherichia coliHydrogen-Ion ConcentrationHydrolysisKineticsRecombinant Fusion ProteinsAryldialkylphosphataseEnzymes, ImmobilizedOrganophosphorus CompoundsRecombinant Fusion ProteinsZeolitesenzyme immobilizationenzyme kinetic parametersorganophosphorus hydrolaseSUMO fusion expressionZIF-F

Identifiers

PMID40141113
PMCPMC11942619

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.