Evidence map›Paper›PMID 40141107›Full record

ArticleInternational journal of molecular sciences2025

CANT1 Is Involved in Collagen Fibrogenesis in Tendons by Regulating the Synthesis of Dermatan/Chondroitin Sulfate Attached to the Decorin Core Protein.

Rina Yamashita, Saki Tsutsui, Shuji Mizumoto, Takafumi Watanabe, Noritaka Yamamoto, Kenta Nakano, Shuhei Yamada, Tadashi Okamura, Tatsuya Furuichi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rina YamashitaLaboratory of Laboratory Animal Science and Medicine, Graduate School of Veterinary Sciences, Iwate University, Morioka 020-8550, Japan.
Saki TsutsuiLaboratory of Laboratory Animal Science and Medicine, Co-Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka 020-8550, Japan.
Shuji MizumotoDepartment of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan.ORCID 0000-0002-4641-1505
Takafumi WatanabeLaboratory of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069-8501, Japan.
Noritaka YamamotoDepartment of Mechanical Engineering, Ritsumeikan University, Kusatsu 525-8577, Japan.
Kenta NakanoDepartment of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine (NCGM), Shinjuku-ku 162-8655, Japan.ORCID 0000-0003-2617-1468
Shuhei YamadaDepartment of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan.ORCID 0000-0002-1284-9795
Tadashi OkamuraDepartment of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine (NCGM), Shinjuku-ku 162-8655, Japan.ORCID 0000-0001-8457-1561
Tatsuya FuruichiLaboratory of Laboratory Animal Science and Medicine, Graduate School of Veterinary Sciences, Iwate University, Morioka 020-8550, Japan.

Funding

Japan Society for the Promotion of Science 21K0593219 and 24K01919 for T.F., 23K06142 for S.M.
6 · The paper itself

Abstract

Tendons are connective tissues that join muscles and bones and are rich in glycosaminoglycans (GAGs). Decorin is a proteoglycan with one dermatan sulfate (DS) or chondroitin sulfate (CS) chain (a type of GAG) attached to its core protein and is involved in regulating the assembly of collagen fibrils in the tendon extracellular matrix (ECM). Calcium-activated nucleotidase 1 (CANT1), a nucleotidase that hydrolyzes uridine diphosphate into uridine monophosphate and phosphate, plays an important role in GAG synthesis in cartilage. In the present study, we performed detailed histological and biochemical analyses of the tendons from

Indexed as

Chondroitin SulfatesCollagenDecorinDermatan SulfateTendonsAnimalsExtracellular MatrixFibroblastsFibrosisMiceMice, KnockoutTenocytesChondroitin SulfatesCollagenDcn protein, mouseDecorinDermatan SulfateCANT1chondroitin sulfatecollagen fibrildecorindermatan sulfateDesbuquois dysplasiaglycosaminoglycanproteoglycantendon

Identifiers

PMID40141107
PMCPMC11941851

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.