Evidence map›Paper›PMID 40141087›Full record

ArticleInternational journal of molecular sciences2025

Multi-Ancestry Transcriptome-Wide Association Studies of Cognitive Function, White Matter Hyperintensity, and Alzheimer's Disease.

Dima L Chaar, Zheng Li, Lulu Shang, Scott M Ratliff, Thomas H Mosley, Sharon L R Kardia, Wei Zhao, Xiang Zhou, Jennifer A Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Special Issue: The Role of Genetics in Dementia.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dima L ChaarDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6755-0179
Zheng LiDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5826-1316
Lulu ShangDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Scott M RatliffDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Thomas H MosleyMemory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0003-3343-1352
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4032-5745
Xiang ZhouDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4331-7599
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3575-5468

Funding

Genetics of Microangiopathic Brain InjuryR01NS041558 · NINDS · MAYO CLINIC ROCHESTER · PI TURNER, STEPHEN T · 2001 to 2010
$5.8M
Genomic Predictors of Arteriosclerosis in HypertensivesR01HL087660 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2007 to 2009
$5.1M
GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPSU01HL054457 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2000 to 2004
$2.8M
Epigenetics of Arteriosclerosis in African American Hypertensive SibshipsR01HL133221 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, JENNIFER ANN · 2016 to 2019
$2.2M
Genetic Mechanisms of Arteriosclerosis in Hypertensive SibshipsR01HL119443 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2014 to 2017
$2.1M
Epigenetic Biomarkers of Common Chronic DiseasesRC1HL100185 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2009 to 2010
$999k
NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01HL087660NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01HL119443NHLBI NIH HHS R01 HL133221NHLBI NIH HHS R01HL133221NHLBI NIH HHS RC1 HL100185NHLBI NIH HHS RC1HL100185NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01HL054457NINDS NIH HHS R01 NS041558NINDS NIH HHS R01NS041558
6 · The paper itself

Abstract

Genetic variants increase the risk of neurocognitive disorders in later life, including vascular dementia (VaD) and Alzheimer's disease (AD), but the precise relationships between genetic risk factors and underlying disease etiologies are not well understood. Transcriptome-wide association studies (TWASs) can be leveraged to better characterize the genes and biological pathways underlying genetic influences on disease. To date, almost all existing TWASs on VaD and AD have been conducted using expression studies from individuals of a single genetic ancestry, primarily European. Using the joint likelihood-based inference framework in Multi-ancEstry TRanscriptOme-wide analysis (METRO), we leveraged gene expression data from European ancestry (EA) and African ancestry (AA) samples to identify genes associated with general cognitive function, white matter hyperintensity (WMH), and AD. Regions were fine-mapped using Fine-mapping Of CaUsal gene Sets (FOCUS). We identified 266, 23, 69, and 2 genes associated with general cognitive function, WMH, AD (using EA GWAS summary statistics), and AD (using AA GWAS), respectively (Bonferroni-corrected alpha =

Indexed as

Alzheimer DiseaseCognitionTranscriptomeWhite MatterAgedBlack PeopleFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideWhite PeopleAlzheimer’s diseasecognitive functiondementiamulti-ancestrytranscriptome-wide association studyvascular dementiawhite matter hyperintensity

Identifiers

PMID40141087
PMCPMC11942532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.