Evidence map›Paper›PMID 40141057›Full record

ArticleInternational journal of molecular sciences2025

C-Terminal Extended Domain-Independent Telomere Maintenance: Modeling the Function of TIN2 Isoforms in

Chiao-Ming Huang, Yi-Ling Shen, Chia-Lo Ho, Tzeng-Erh Chen, Hsuan-Yu Hsia, Zhou Songyang, Liuh-Yow Chen

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chiao-Ming HuangMolecular and Cell Biology, Taiwan International Graduate Program, Academia Sinica and Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0002-0116-1098
Yi-Ling ShenInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.
Chia-Lo HoInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.
Tzeng-Erh ChenInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.ORCID 0009-0008-9200-9948
Hsuan-Yu HsiaInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.
Zhou SongyangSun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510275, China.
Liuh-Yow ChenMolecular and Cell Biology, Taiwan International Graduate Program, Academia Sinica and Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0002-9857-068X

Funding

Academia Sinica AS-GCP-113-L02
6 · The paper itself

Abstract

TIN2 (TERF1 interacting nuclear factor 2) is a telomeric shelterin complex component, essential for telomere protection and early embryonic development in mammals. In humans, TIN2 isoforms arise from alternative splicing, but their specific roles in vivo remain unclear. Here, we explore TIN2 isoform functions in the laboratory mouse

Indexed as

TelomereTelomere-Binding ProteinsTelomere HomeostasisAlternative SplicingAnimalsFibroblastsHumansMiceProtein DomainsProtein IsoformsProtein IsoformsTelomere-Binding ProteinsTinf2 protein, mousealternative splicingDNA damagetelomere

Identifiers

PMID40141057
PMCPMC11941968

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.