Evidence map›Paper›PMID 40141054›Full record

ArticleInternational journal of molecular sciences2025

Neuroprotective Activity of Oligomeric Stilbenes from Alpha Grape Stems in In Vitro Models of Parkinson's Disease.

Evgeny A Pislyagin, Darya V Tarbeeva, Ekaterina A Yurchenko, Ekaterina S Menchinskaya, Tatiana Y Gorpenchenko, Natalya D Pokhilo, Anatoly I Kalinovskiy, Dmitry L Aminin, Sergey A Fedoreyev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Anthonoic Acids A-C, Sulfated andMolecules (Basel, Switzerland) · 2025
    Article
  4. Plants, Pills, and the Brain: Exploring Phytochemicals and Neurological Medicines.International journal of plant, animal and environmental sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Evgeny A PislyaginG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.ORCID 0000-0002-3558-0821
Darya V TarbeevaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.ORCID 0000-0003-1769-3627
Ekaterina A YurchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.ORCID 0000-0001-7737-0980
Ekaterina S MenchinskayaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.
Tatiana Y GorpenchenkoFederal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.ORCID 0000-0002-9419-7523
Natalya D PokhiloG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.
Anatoly I KalinovskiyG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.
Dmitry L AmininG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.ORCID 0000-0002-1073-4994
Sergey A FedoreyevG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690022, Russia.ORCID 0000-0002-4199-2099

Funding

Russian Science Foundation 24-74-10081
6 · The paper itself

Abstract

This study investigated the neuroprotective activity of oligomeric stilbenes (OSs) derived from Alpha grape stems in various in vitro models of Parkinson's disease (PD). Using neurotoxin-induced cellular models, including 1-methyl-4-phenylpyridine (MPP+), paraquat (PQ), 6-hydroxydopamine (6-OHDA), and rotenone, we screened the cytoprotective effects of ampelopsin A (

Indexed as

Neuroprotective AgentsParkinson DiseasePlant StemsStilbenesVitisAnimalsAntioxidantsCell Line, TumorCell SurvivalHumansMiceMitochondriaOxidative StressOxidopamineReactive Oxygen SpeciesAntioxidantsNeuroprotective AgentsOxidopamineReactive Oxygen SpeciesStilbenesantioxidant mechanismsneuro-2a cellsneuroprotective activityoligomeric stilbenesoxidative stressParkinson’s diseasereactive oxygen species

Identifiers

PMID40141054
PMCPMC11942555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.