Evidence map›Paper›PMID 40141051›Full record

ArticleInternational journal of molecular sciences2025

Age- and ApoE Genotype-Dependent Transcriptomic Responses to O

Mary F Nakamya, Kaili Hu, Chunsun Jiang, Zechen Chong, Rui-Ming Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mary F NakamyaDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Kaili HuDepartment of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-9461-1328
Chunsun JiangDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Zechen ChongDepartment of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rui-Ming LiuDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0003-0751-5579

Funding

Structural variation analysis with and without a reference genomeR35GM138212 · NIGMS · UNIVERSITY OF VIRGINIA · PI Zechen Chong · 2020 to 2026
$2.6M
Sex-dependent synergy between O3 exposure, APOE4 e4 genotype, and aging in the onset of Alzheimer's diseaseR01AG077395 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RUI-MING LIU · 2023 to 2026
$1.8M
Ozone, apoE4, aging, and Alzheimer's diseaseR21AG046701 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIU, RUI-MING · 2013 to 2015
$424k
NIA NIH HHS R01 AG077395NIA NIH HHS R21 AG046701NIGMS NIH HHS R35 GM138212NIH HHS R01AG077395NIH HHS R21AG046701
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a leading cause of dementia in the elderly, with late-onset AD (LOAD) accounting for 95% of the cases. The etiology underlying LOAD, however, remains unclear. Using a humanized mouse model, we showed previously that exposure to ozone (O

Indexed as

AgingAlzheimer DiseaseApolipoproteins EHippocampusOzoneTranscriptomeAnimalsApolipoprotein E3Apolipoprotein E4Disease Models, AnimalGenotypeHumansMaleMiceMice, TransgenicApolipoprotein E3Apolipoprotein E4Apolipoproteins EOzoneagingAlzheimer’s diseaseAPOEneurogenesisoxidative stressozonesynaptic function

Identifiers

PMID40141051
PMCPMC11942628

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.