Evidence map›Paper›PMID 40141048›Full record

ReviewInternational journal of molecular sciences2025

Histone Phosphorylation in DNA Damage Response.

Ping Gong, Zhaohui Guo, Shengping Wang, Shufeng Gao, Qinhong Cao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ping GongHunan Institute of Microbiology, Changsha 410009, China.
Zhaohui GuoHunan Institute of Microbiology, Changsha 410009, China.
Shengping WangHunan Institute of Microbiology, Changsha 410009, China.
Shufeng GaoHunan Institute of Microbiology, Changsha 410009, China.
Qinhong CaoCollege of Biological Sciences, China Agricultural University, No.2 Yuan-Ming-Yuan West Road, Beijing 100193, China.ORCID 0000-0002-2055-3513

Funding

Beijing Municipal Natural Science Foundation 5212010National Natural Science Foundation of China 32100069
6 · The paper itself

Abstract

The DNA damage response (DDR) is crucial for maintaining genomic stability and preventing the accumulation of mutations that can lead to various diseases, including cancer. The DDR is a complex cellular regulatory network that involves DNA damage sensing, signal transduction, repair, and cell cycle arrest. Modifications in histone phosphorylation play important roles in these processes, facilitating DNA repair factor recruitment, damage signal transduction, chromatin remodeling, and cell cycle regulation. The precise regulation of histone phosphorylation is critical for the effective repair of DNA damage, genomic integrity maintenance, and the prevention of diseases such as cancer, where DNA repair mechanisms are often compromised. Thus, understanding histone phosphorylation in the DDR provides insights into DDR mechanisms and offers potential therapeutic targets for diseases associated with genomic instability, including cancers.

Indexed as

DNA DamageDNA RepairHistonesAnimalsGenomic InstabilityHumansPhosphorylationSignal TransductionHistonesDNA damage responseDNA repairhistone phosphorylationkinaseγH2AX

Identifiers

PMID40141048
PMCPMC11941871

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.