Evidence map›Paper›PMID 40141027›Full record

ArticleInternational journal of molecular sciences2025

Hypertrophic Cardiomyopathy-Associated CRYAB

Andres Thorkelsson, Chun Chou, Audrey Tripp, Samia A Ali, Jonas Galper, Michael T Chin

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andres ThorkelssonMD Program, Tufts University School of Medicine, Boston, MA 02111, USA.
Chun ChouMD Program, Tufts University School of Medicine, Boston, MA 02111, USA.
Audrey TrippMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
Samia A AliGenetics, Molecular and Cellular Biology Program, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
Jonas GalperMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
Michael T ChinMD Program, Tufts University School of Medicine, Boston, MA 02111, USA.ORCID 0000-0003-3065-8498

Funding

Tufts Post-Baccalaureate Research Education ProgramR25GM066567 · NIGMS · TUFTS UNIVERSITY BOSTON · PI RIOS, MARIBEL · 2002 to 2024
$5.7M
NIGMS NIH HHS R25 GM066567
6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular condition in the world, affecting around 1 in 500 people. HCM is characterized by ventricular wall thickening, decreased ventricular chamber volume, and diastolic dysfunction. Inherited HCM is most commonly caused by sarcomere gene mutations; however, approximately 50% of patients do not present with a known mutation, highlighting the need for further research into additional pathological mutations. The alpha-B crystallin (CRYAB) mutation CRYAB

Indexed as

alpha-Crystallin B ChainCalcineurinCalciumCardiomyopathy, HypertrophicAnimalsCell LineDisease Models, AnimalHumansMaleMiceMutationProtein BindingProteomeProteomicsRatsalpha-Crystallin B ChainCalcineurinCalciumProteomealpha-B-crystallinAlphaFoldcalcineurincardiac hypertrophyCRYABhypertrophic cardiomyopathymass spectrometrymolecular chaperonetransverse aortic constriction

Identifiers

PMID40141027
PMCPMC11941971

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.