Evidence map›Paper›PMID 40141010›Full record

ArticleBMC infectious diseases2025

Biological profile and risk factors of mortality in COVID-19 patients at Adlucem hospital in Banka-Bafang, Cameroon: a cross-sectional study.

Bertin Mamere Atangana Awundja, Boris Ronald Tonou Tchuente, Vervaine Pauline Hagbe, Leila Sandra Nnanga, Linda Kamdem, Dudric Yannick Enonguene Ekedjoum, Onana Messi Hubert Roger, Belomo Maguerrite, Dehayem Patricia, Julius Achidi Ndanji and 4 more

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Bertin Mamere Atangana AwundjaDepartment of Biochemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, P.O. Box 812, Cameroon.
Boris Ronald Tonou TchuenteDepartment of Biochemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, P.O. Box 812, Cameroon.
Vervaine Pauline HagbeDepartment of Biochemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, P.O. Box 812, Cameroon.
Leila Sandra NnangaDepartment of Biochemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, P.O. Box 812, Cameroon.
Linda KamdemINSERM, U1059, DVH Team, SAINBIOSE, Jean Monnet University Saint-Etienne, University Hospital of Saint-Etienne, Saint-Etienne, France.
Dudric Yannick Enonguene EkedjoumFaculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Onana Messi Hubert RogerAd-lucem Banka-Bafang Hospital, Bafang, Cameroon.
Belomo MaguerriteAd-lucem Banka-Bafang Hospital, Bafang, Cameroon.
Dehayem PatriciaAd-lucem Banka-Bafang Hospital, Bafang, Cameroon.
Julius Achidi NdanjiAd-lucem Banka-Bafang Hospital, Bafang, Cameroon.
Leonel Javeres Ntepe MbahLaboratory of Human Metabolism and Non-Communicable Disease, Institute of Medical Research and Medicinal Plant Studies, Yaounde, Cameroon.
Evelyn Ngwa LumngwenaSchool of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Bienvenu BongueINSERM, U1059, DVH Team, SAINBIOSE, Jean Monnet University Saint-Etienne, University Hospital of Saint-Etienne, Saint-Etienne, France.
Judith Laure NgondiDepartment of Biochemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, P.O. Box 812, Cameroon. ngondijudithl@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite availability of preventive vaccine and global control of the SARS-CoV-19 transmission, continuous emergence of new strains coupled with the increase spread of Mpox poses significant public health threats. Identification of simple factors for stratification and prognostics of hospitalized patients is crucial for management of these patients in limited resource settings. The aim of this study was to assess the biological profile of severe hospitalized COVID-19 patients in Cameroon and identify risk factors for mortality.

methodsA prospective, cross-sectional, analytical study was conducted of a cohort of COVID-19 patients admitted and managed at the Adlucem hospital in Banka-Bafang, Haut-Nkam Department, West Cameroon Region, from 2021 to 2022. The clinical characteristics and biological parameters of patients with COVID-19 were evaluated.

resultsOf the 259 cases of COVID-19 included in the study, 68 cases (26.3%) died. The majority of patients who died were over 70 years of age. Key factors predictive of mortality in these patients were leukocytosis (OR = 2.035; 95%CI: 1.161-3.567; p = 0.013), thrombocytosis (OR = 4.286; 95%CI: 1.152-15.950; p = 0.030), hypokalemia (OR = 2.400; 95%CI: 1.143-5.042; p = 0.021), hyponatremia (OR = 2.292; 95%CI: 1.185-4.431; p = 0.014) and hypochloremia (OR = 2.644; 95%CI: 1.188-5.882; p = 0.017).

conclusionAge, electrolyte imbalance and thrombocytosis were predictive of death in COVID-19 patients in this cohort. Thus, a biological work-up should be considered for risk stratification to ensure efficient management of COVID-19 patients on a case-by-case basis in resource limited settings like Cameroon. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

COVID-19AdultAgedAged, 80 and overCameroonCross-Sectional StudiesFemaleHospitalizationHumansMaleMiddle AgedProspective StudiesRisk FactorsSARS-CoV-2Biological profileCameroonCOVID-19DeathRisk factors

Identifiers

PMID40141010
PMCPMC11948750

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.