ArticleCancer imaging : the official publication of the International Cancer Imaging Society2025
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Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A prospective, exploratory study ofEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Coexisting papillary and medullary thyroid carcinomas in a 60 year old male: a case report.Annals of medicine and surgery (2012) · 2025Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile total thyroidectomy with central neck dissection (CND) is standard for medullary thyroid cancer (MTC), performing a lateral neck dissection (LND) depends on locoregional metastatic spread and is usually decided per individual. This study evaluated the utility of preoperative PET/CT in staging patients at diagnosis and guiding the initial surgical plan, while also exploring the value of neck ultrasound, MRI, and CT.
methodsAll MTC patients from two tertiary hospitals (2000 - 2020) were identified from two retrospective databases. All reports of neck ultrasounds, MRIs, CTs and PET/CTs < 8 months prior to primary surgery or < 4 months after MTC diagnosis were reviewed. The sensitivity and specificity of each imaging modality for locating locoregional lymph node metastases (LNM) was determined.
resultsA total of 175 MTC patients were included (91 females and 57 hereditary MTCs). Median age at presentation was 52 years (IQR 38 - 62). Initial treatment included a total thyroidectomy, CND and LND in 155 (89%), 140 (80%) and 59 (33%) patients. Preoperative imaging of the neck included ultrasound (91, 52%), MRI (33, 19%) and CT (31, 18%). PET/CT imaging was performed in 56 (32%) patients (35
conclusionsPET/CT is a powerful tool to detect locoregional LNM and can particularly help identify cases where LNDs are required, avoiding reoperation later on. For accurate staging of the central neck, PET may be combined with diagnostic CT. Finally, PET/CT's ability to detect distant metastases may support de-escalation of a surgical intervention when cure is unlikely.
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