ArticleBMC chemistry2025
Temperature-dependent solubilization and thermodynamic characteristics of ribociclib in varied {PEG 400 + water} combinations.
Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
The solubility and thermodynamic characteristics of ribociclib (RCB), a new anticancer medication, have been assessed in a range of {polyethylene glycol 400 (PEG 400) + water} combinations at 293.2-313.2 K and atmospheric pressure. RCB solubility was determined utilizing the saturation shake flask approach, and "van't Hoff, Apelblat, Buchowski-Ksiazczak λh, Yalkowsky-Roseman, Jouyban-Acree, and Jouyban-Acree-van't Hoff models" were utilized to validate the measured experimental data. The uncertainties for the computational predictions were less than 3.0% throughout the validation, indicating an outstanding relationship with the experimental RCB solubility data. PEG 400 mass fraction and temperature both improved the solubility of RCB in mole fraction in the compositions of {PEG 400 + water}. It was discovered that the RCB solubility in mole fraction was greatest in pure PEG 400 (1.04 × 10
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