ReviewInfectious diseases of poverty2025
Reassessing Schistosoma worms: the overlooked role in host pathology and disease elimination.
Review in Infectious diseases of poverty, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Commentary: Induction of hepatic fibrosis in mice with schistosomiasis by extracellular microRNA-30 derived fromFrontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSchistosomiasis, a neglected tropical disease, remains a pressing global health challenge, hindering progress toward achievement of the Sustainable Development Goals (SDGs) in endemic regions. Despite advances in control strategies, including preventive chemotherapy and integrated measures, the elimination of schistosomiasis remains an elusive goal. Current understanding of schistosomiasis pathogenesis has largely focused on egg-induced pathology, while the contributions of schistosome worms to disease progression are relatively underexplored. The objective of this article is to highlight the critical, yet overlooked, role of schistosome worms in disease progression and to advocate for a broader research focus on their direct impact on host pathology and efforts towards disease elimination. MAIN TEXT: Single-sex schistosome infections, which may occur in low-transmission areas, deserve greater attention as they evade traditional egg-based diagnostics. These infections also provide a valuable model to explore the direct contributions of worms to host pathology. Recent studies suggest that schistosome worms, via their excretory-secretory products (ESPs), contribute to liver inflammation, fibrosis, and immune modulation independent of egg deposition. Understanding the interactions between worms and hosts is essential for elucidating their role in disease progression. Furthermore, the potential similarities between schistosome ESPs and those of carcinogenic trematodes highlight the need for further investigation into their long-term impact on host health and schistosomiasis pathology.
conclusionsExpanding the focus of schistosomiasis research to include the role of schistosome worms is essential for advancing diagnostic and therapeutic strategies. By incorporating single-sex infection models and targeting worm-derived molecules, it is possible to uncover the overlooked aspects of schistosomiasis pathogenesis, improve diagnostic accuracy, and support global elimination efforts, thereby contributing to the realization of the SDGs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.