Observational studyBMC musculoskeletal disorders2025
Associations between estimated glucose disposal rate and osteoarthritis risk in US adults: a cross-sectional study.
Observational study in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Association between Osteoarthritis and the Triglyceride-Glucose Index in the Korean Population: A Large-Scale Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Association of eight anthropometric indexes related to obesity with the prevalence of clinical osteoarthritis among American adults: a national cross-sectional study.European journal of medical research · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundEstimated glucose disposal rate (eGDR) is a novel insulin resistance (IR) assessment surrogate. Although it has shown promising potential in other metabolic disease studies, no research has yet explored its relationship with osteoarthritis (OA). Therefore, this study aims to investigate the association between eGDR and OA in a cross-sectional observational cohort.
methodData utilized in this cross-sectional study were drawn from the National Health and Nutrition Examination Survey (NHANES). Logistic regression models were used to evaluate the association between eGDR and OA, stratified analysis was applied to assess the stability of the results.
resultA total of 19,040 participants were included in the study, including 2,001 OA patients and 17,039 non-OA participants with an age distribution ranging from 20 to 85 years. The fully adjusted logistic regression model shows that eGDR were less likely associated with OA compared to those with non-OA (OR = 0.879, 95% CI = 0.846-0.914, P < 0.001). By dispersing the eGDR into quartiles, the correlation between eGDR and OA remained significant (P for trend < 0.0001).
conclusionThis study suggests that eGDR is independently associated with OA, with lower eGDR values being linked to a higher risk of OA. CLINICAL TRIAL NUMBER: Not applicable.
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