Evidence map›Paper›PMID 40140834›Full record

ArticleMalaria journal2025

False alarm on a malaria "outbreak" linked to inconsistencies in malaria diagnostic supply: a call to strengthen supply chain management: Sierra Leone, May-July 2023.

Timothy N DeVita, Aminata B Kabia, James A M Khobi, Mugagga Malimbo, Samba Kamara, Bridget Magoba, Gebrekrstos N Gebru, Anna H Jammeh, John A Painter, Thomas K Ansumana and 2 more

Abstract read
In one paragraph

Article in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Timothy N DeVitaMalaria Branch, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA. uqt3@cdc.gov.
Aminata B KabiaAfrican Field Epidemiology Network, Freetown, Sierra Leone.
James A M KhobiAfrican Field Epidemiology Network, Freetown, Sierra Leone.
Mugagga MalimboWorld Health Organization, Freetown, Sierra Leone.
Samba KamaraUnited States President's Malaria Initiative, United States Agency for International Development, Freetown, Sierra Leone.
Bridget MagobaAfrican Field Epidemiology Network, Freetown, Sierra Leone.
Gebrekrstos N GebruAfrican Field Epidemiology Network, Freetown, Sierra Leone.
Anna H JammehAfrican Field Epidemiology Network, Freetown, Sierra Leone.
John A PainterMalaria Branch, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Thomas K AnsumanaMinistry of Health, Freetown, Sierra Leone.
Musa Sillah-KanuMinistry of Health, Freetown, Sierra Leone.
David C SchnabelUnited States President's Malaria Initiative, Centers for Disease Control and Prevention, Freetown, Sierra Leone.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundMalaria transmission in Sierra Leone is intense and perennial, accounting for 40% of clinical consultations. Medical workers diagnose suspected malaria cases using rapid diagnostic tests (RDT) and microscopy, with facility-level results reported to the Health Management Information System (HMIS) as monthly aggregates. Commodity stocks are reported to the Logistics Management Information System (LMIS). Partners investigated a striking increase in confirmed malaria during May-July 2023 in Sierra Leone, peaking in June to 46% above the June 2018-2022 mean.

methodsThe team first analysed national, district, and facility HMIS/LMIS data for RDT stocks, testing rates, and confirmed cases during January 2018-October 2023. Epidemic thresholds, defined as case counts two standard deviations (σ) above the previous 5 years' monthly mean, were assessed. Then four facilities in two districts were visited to interview staff. Lastly, the team reanalysed LMIS RDT stock data for all facilities in Sierra Leone using R to categorize their stock status by month.

resultsNational epidemic thresholds were surpassed in May (2.56σ) and June (4.81σ) 2023. Twelve of sixteen districts surpassed epidemic thresholds during May-June. Investigation revealed inconsistent RDT distribution to facilities over time. National RDT distribution spiked in May 2023, when 551,888 RDT test kits were delivered. This was substantially larger than the 2019-2022 mean for May (53,121, 1,000% increase) and all months (126,866, 435% increase). Subsequently in June 2023, 386,343 tests were performed, 36% higher than the June 2018-2022 mean (285,123). Staff at all four visited facilities reported recurrent RDT stockouts. The proportion of facilities in Sierra Leone reporting positive RDT stocks at both the start and end of the month increased from 14% in April to 74% in June. 51% of facilities began May with RDT stockout and received RDTs that month.

conclusionsThe 2023 spike in confirmed malaria was likely related to increased testing following an unusually large distribution of RDTs. Fluctuations in RDT availability impede the ability to recognize true case variations. Sierra Leone and its partners can strengthen supply chain logistics and health commodity stock tracking to ensure a consistent supply of RDTs and improve interpretation of surveillance data.

Indexed as

Diagnostic Tests, RoutineDisease OutbreaksMalariaHumansSierra Leone

Identifiers

PMID40140834
PMCPMC11948700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.