ArticleBMC endocrine disorders2025
Association of the inflammatory burden index with the risk of pre-diabetes and diabetes mellitus: a cross-sectional study.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Multicenter cohort study reveals: composite inflammatory indexs are associated with increased risk of diabetes in patients with hypertension.Frontiers in endocrinology · 2026Article
- Association of novel inflammatory biomarkers with major amputation level in diabetic foot ulcer patients undergoing amputation: a retrospective comparative study.Frontiers in endocrinology · 2026Article
- Exploring the multifaceted roles of beta-defensins in prediabetes: a detailed review.Frontiers in endocrinology · 2026Review
- Cumulative of c-reactive protein-triglyceride glucose index exposure and risk of diabetes in middle-aged and older Chinese adults: findings from a national longitudinal cohort.Diabetology & metabolic syndrome · 2025Article
- Associations of inflammatory burden index with the prevalence and mortality of asthma in adults: a population based study.Journal of thoracic disease · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
objectiveThis study aims to investigate the association between the Inflammatory Burden Index (IBI) and the prevalence of pre-diabetes (pre-DM) and diabetes mellitus (DM) in the U.S. population from 1999 to 2010. By analyzing relevant data collected during this period, the study seeks to understand IBI's role in the onset of pre-DM and DM and its potential implications for public health.
methodsA cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2010. A total of 29,554 participants were included, with diabetes status determined by self-reported diagnoses and clinical indicators (such as glycosylated hemoglobin and fasting blood glucose). The Inflammatory Burden Index (IBI) was calculated using C-reactive protein (CRP) multiplied by the neutrophil-to-lymphocyte ratio. The generalized additive model (GAM) was employed to examine the relationship between increasing IBI and the incidence of pre-DM and DM.
resultThe study included 29,554 participants, with 14,290 (48.4%) men and 15,264 (51.6%) women, and a mean age of 48.3 years (SD = 19.1). The findings revealed a significant association between IBI and the risk of pre-DM and DM. In the fully adjusted model, a stronger relationship was observed between pre-DM, DM, and IBI. The prevalence of pre-DM and DM was significantly higher in the fourth quartile (Q4) compared to the first quartile (Q1), with a 26% prevalence of pre-DM and an 18% prevalence of DM when IBI was greater than 1.04.
conclusionOur study demonstrates a significant correlation between IBI and the risk of pre-DM and DM in the U.S. POPULATION: Given these findings, we recommend that IBI be considered as a key indicator for the management and treatment of pre-DM and DM in clinical settings.
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