ArticleBMC infectious diseases2025
Association between lactate to albumin ratio and mortality among sepsis associated acute kidney injury patients.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine learning-based mortality risk prediction models in patients with sepsis-associated acute kidney injury: a systematic review.Frontiers in medicine · 2025Pooled it
- Lactate in acute kidney injury: pathobiology, risk stratification, and clinical interpretation.Renal failure · 2026Review
- Late-Course Lactate/Albumin Ratio and In-Hospital Mortality in CRRT-Treated Critically Ill Patients: A Retrospective Severity-Adjusted Analysis.Journal of clinical medicine · 2026Article
- Dynamic Lactate-to-Albumin Ratio Trajectories and Outcomes in Sepsis-Associated Acute Kidney Injury: Evidence From MIMIC-IV and a Multicenter Chinese Cohort.JMIR medical informatics · 2026Observational
- Association between the lactate-to-albumin ratio and mortality in patients with protein-energy malnutrition: a retrospective cohort study.BMC nutrition · 2026Article
- The relationship between lactate-to-albumin ratio and prognosis in patients with sepsis-induced cardiomyopathy: a retrospective cohort study.Scientific reports · 2026Article
- Association between lactate-to-albumin ratio and mortality in patients with sepsis-induced coagulopathy: a retrospective cohort study.Scientific reports · 2026Article
- Association between lactate-to-albumin ratio and 30-day all-cause mortality in patients with acute pancreatitis-associated acute kidney injury.Scientific reports · 2026Article
- Association of lactate-to-albumin ratio with 28-day mortality in elderly sepsis patients: a retrospective MIMIC-IV database analysis.BMC infectious diseases · 2026Article
- Association between lactate-to-albumin ratio and clinical outcomes in perioperative patients with chronic kidney disease: a retrospective cohort study based on INSPIRE database.Clinical and experimental nephrology · 2026Article
- Association between baseline-stratified trajectory subgroups of serum albumin and outcomes in critically ill patients with early sepsis-associated acute kidney injury: a retrospective study.Frontiers in medicine · 2026Article
- The lactate-to-albumin ratio as a potential biomarker for acute kidney injury risk in critically ill patients with heart failure: a retrospective study with real-world external validation.Frontiers in nutrition · 2026Article
- Association between red blood cell distribution width to albumin ratio and prognosis in patients with sepsis-associated acute kidney injury: a retrospective cohort study.Frontiers in medicine · 2026Article
- Protective Effects of Cyclosporin H Against Sepsis-Induced Acute Kidney Injury via Modulation of Fpr1 Signaling and Inhibiting Pyroptosis.Research and reports in urology · 2026Article
- Survival Prediction in Septic ICU Patients: Integrating Lactate and Vasopressor Use with Established Severity Scores.Diseases (Basel, Switzerland) · 2025Article
- Observational
- The role of the Lactate-to-Albumin ratio in predicting ICU admission and mortality in patients with UGIB presenting to the ED: a prospective observational study.BMC emergency medicine · 2025Observational
- The non-linear association between creatinine-to-albumin ratio and medium-term mortality in patients with sepsis accompanied by acute kidney injury in the intensive care unit: a retrospective study based on the MIMIC database and external validation.Frontiers in cellular and infection microbiology · 2025Article
- Clinical impact and safety of continuous renal replacement therapy in critically ill patients with solid tumors and acute kidney injury: a retrospective cohort analysis.American journal of cancer research · 2025Article
- Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis-Associated Acute Kidney Injury (SA-AKI) has high fatality rates, but clear outcome markers are lacking. The objective of this research was to ascertain the link between lactate-to-albumin ratio (LAR) and mortality in cases of SA-AKI.
methodsWe performed a retrospective cohort analysis of 3589 critically ill patients with SA-AKI using the Intensive Care Medical Information Mart IV (MIMIC-IV) database. Patients were categorized into four groups based on the quartiles of LAR. The findings of this study provide baseline data and outcomes regarding in-hospital, 30-day, and 90-day mortality rates for SA-AKI patients in the intensive care unit. We utilized multivariate cox regression analysis to compute the adjusted hazard ratio (HR) and 95% confidence intervals (95% CI). Subgroup analysis and restricted cubic spline curves were employed to further investigate the relationship between LAR and mortality.
resultsThis study involved 3589 participants with a mean age of 62.5 years. Patients in the LAR group with a Q4 (LAR ≥ 0.95) were associated with an increased risk of in-hospital mortality, 30-day mortality, and 90-day mortality (hazards ratio (HR): 2.11, 95% CI:1.7-2.62; HR: 1.9, 95% CI: 1.55-2.34; HR: 1.91, 95% CI: 1.58-2.31, respectively). Notably, within the subgroup of patients with AKI stages 2 and no CHF patients, the association between LAR and mortality was more pronounced.
conclusionThe research underscores that elevated LAR are linked to heightened mortality risks. Notably, subgroup analyses have demonstrated that the correlation between LAR and mortality is particularly robust in certain patient cohorts, most notably those with stage 2 AKI and those without congestive heart failure (CHF). CLINICAL TRIAL NUMBER: Not applicable.
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