Evidence map›Paper›PMID 40140761›Full record

ArticleBMC pulmonary medicine2025

Comparing the clinical characteristics and risk factors of prognosis in pediatric ARDS with and without malignancies: a retrospective cohort study.

Xi Xiong, Yun Cui, Chunxia Wang, Yiping Zhou, Xiaoxuan Ma, Pin Li, Yucai Zhang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xi XiongDepartment of Critical Care Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Yun CuiDepartment of Critical Care Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Chunxia WangDepartment of Critical Care Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Yiping ZhouDepartment of Critical Care Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Xiaoxuan MaDepartment of Critical Care Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Pin LiDepartment of Endocrinology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. lipin2019@126.com.
Yucai ZhangDepartment of Critical Care Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. zyucai2018@163.com.

Funding

National Key Research and Development Program of China 2021YFC2701800National Natural Science Foundation of China 82100085Science and Technology Commission of Shanghai Municipality 18411951000Shanghai Municipal Health Commission Special Project for Clinical Research in the Healthcare Industry 20244Y0020
6 · The paper itself

Abstract

backgroundThe number of malignancy patients with respiratory failure is rising in pediatric intensive care units (PICU). Our study aims to compare the clinical characteristics and prognostic risk factors of acute respiratory distress syndrome (ARDS) with or without malignancies.

methodsThis retrospective study reviewed medical records of 188 ARDS patients admitted to the PICU between January 2018 and December 2022, including 60 with malignancies and 128 without. Clinical data were collected within 48 h post-ARDS diagnosis. Multivariate logistic regression analysis and receiver operating characteristic curve (ROC) analysis were used to investigate the risk factors for PICU mortality in the malignancy and non-malignancy groups.

resultsCompared with pediatric patients without malignancy, the ARDS patients with malignancy presented higher mortality (55.0% vs. 31.3%, P = 0.002), a higher incidence of community-acquired fungal infection (36.1% vs. 6.3%, P < 0.001) and multidrug resistance (MDR) bacteria (65.4% vs. 30.5%, P = 0.003). There were substantial differences in levels of lactate [1.5 (0.8-3.7) vs. 1.0 (0.7-2.0) mmol/L, P = 0.008], C-reactive protein (CRP) [150.0 (83.0-168.0) vs. 31.0 (10.0-108.0) mg/L, P = 0.02], procalcitonin (PCT) [10.4 (2.0-27.5) vs. 1.2 (0.3-6.2) mg/L, P < 0.001], counts of platelet [17.0 (8.0-73.0) vs. 232.0 (152.0-330.0) × 10

conclusionARDS patients with malignancies exhibited poorer outcomes. VIS is only an independent predictor of mortality in pediatric ARDS patients with malignancies.

Indexed as

NeoplasmsRespiratory Distress SyndromeAdolescentChildChild, PreschoolC-Reactive ProteinFemaleHumansInfantIntensive Care Units, PediatricMalePrognosisRetrospective StudiesRisk FactorsROC CurveC-Reactive ProteinAcute respiratory distress syndromeChildrenMalignanciesVasoactive inotropic score

Identifiers

PMID40140761
PMCPMC11938634

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