Evidence map›Paper›PMID 40140730›Full record

ArticleScientific reports2025

Honey bee egg composition changes seasonally and after acute maternal virus infection.

Abigail Chapman, Alison McAfee, Kenzie L C Wrightson, Armando Alcazar Magaña, David R Tarpy, Julia D Fine, Zoe Rempel, Kira Peters, Rob W Currie, Shelley E R Hoover and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abigail ChapmanMichael Smith Laboratories, Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, Canada. abigail.chapman@ubc.ca.
Alison McAfeeMichael Smith Laboratories, Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, Canada.
Kenzie L C WrightsonMichael Smith Laboratories, Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, Canada.
Armando Alcazar MagañaMichael Smith Laboratories, Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, Canada.
David R TarpyDepartment of Applied Ecology, North Carolina State University, Raleigh, NC, USA.
Julia D FineInvasive Species and Pollinator Health Research Unit, USDA-ARS, Davis, CA, USA.
Zoe RempelDepartment of Entomology, University of Manitoba, Winnipeg, MB, Canada.
Kira PetersDepartment of Entomology, University of Manitoba, Winnipeg, MB, Canada.
Rob W CurrieDepartment of Entomology, University of Manitoba, Winnipeg, MB, Canada.
Shelley E R HooverDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada.
Leonard J FosterMichael Smith Laboratories, Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, Canada.

Funding

National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
Biomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2M
Genome BC 374PROGenome Canada 264PRONIDDK NIH HHS U2C DK119886NIH HHS OT2 OD030544
6 · The paper itself

Abstract

Honey bee (Apis mellifera) colonies depend on the reproductive output of their queens, which in turn is contingent on the care they receive from worker bees. Viral infections in queens can compromise their reproductive output, while viral infections in workers can inhibit the successful functioning of the colony and its ability to care for the queen. Transgenerational immune priming (TGIP) occurs when queens transfer immune-related compounds or immune elicitors to their offspring, enhancing the ability of subsequent generations to resist infections. These maternal effects on offspring could positively impact colony health and resilience to viral infections, but little is currently known about TGIP for viruses in honey bees. In this study, we investigate how viral infections affect the proteomic composition of eggs laid by queens injected with a mixture of black queen cell virus and deformed wing virus B, both in controlled experimental settings and natural field conditions. Our results showed that virus-challenged queens upregulated immune effectors in their eggs and ovaries. In contrast, naturally infected queens from field surveys did not; there were no significant differences in egg protein, lipid, or metabolite composition related to maternal viral load or ovary size. However, egg collection date strongly influenced the protein, lipid, and metabolite composition of eggs, potentially reflecting seasonal variations in pollen resources. These findings suggest that while viral infections can induce transgenerational effects on egg proteomes under short-term experimental conditions, such effects are less apparent in natural settings and can be overshadowed by seasonal and other ecological factors.

Indexed as

OvumAnimalsBeesDicistroviridaeFemaleProteomeProteomicsRNA VirusesSeasonsProteome

Identifiers

PMID40140730
PMCPMC11947112

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.