Evidence map›Paper›PMID 40140606›Full record

ReviewNature human behaviour2025

Socio-economic status is a social construct with heritable components and genetic consequences.

Abdel Abdellaoui, Hilary C Martin, Martin Kolk, Adam Rutherford, Michael Muthukrishna, Felix C Tropf, Melinda C Mills, Brendan P Zietsch, Karin J H Verweij, Peter M Visscher

Abstract readReview
In one paragraph

Review in Nature human behaviour, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abdel AbdellaouiDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. a.abdellaoui@amsterdamumc.nl.ORCID http://orcid.org/0000-0003-1088-6784
Hilary C MartinHuman Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0002-4454-9084
Martin KolkDemography Unit, Department of Sociology, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7175-4040
Adam RutherfordDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Michael MuthukrishnaDepartment of Psychological and Behavioural Science, London School of Economics and Political Science, London, UK.ORCID http://orcid.org/0000-0002-7079-5166
Felix C TropfCentre for Longitudinal Studies, University College London, London, UK.ORCID http://orcid.org/0000-0003-2445-515X
Melinda C MillsLeverhulme Centre for Demographic Science, Nuffield Department of Population Health and Nuffield College, University of Oxford, Oxford, UK.
Brendan P ZietschCentre for Psychology and Evolution, School of Psychology, University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-0274-6140
Karin J H VerweijDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-9868-7821
Peter M VisscherBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-2143-8760

Funding

Wellcome Trust 220540
6 · The paper itself

Abstract

In civilizations, individuals are born into or sorted into different levels of socio-economic status (SES). SES clusters in families and geographically, and is robustly associated with genetic effects. Here we first review the history of scientific research on the relationship between SES and heredity. We then discuss recent findings in genomics research in light of the hypothesis that SES is a dynamic social construct that involves genetically influenced traits that help in achieving or retaining a socio-economic position, and can affect the distribution of genes associated with such traits. Social stratification results in people with differing traits being sorted into strata with different environmental exposures, which can result in evolutionary selection pressures through differences in mortality, reproduction and non-random mating. Genomics research is revealing previously concealed genetic consequences of the way society is organized, yielding insights that should be approached with caution in pursuit of a fair and functional society.

Indexed as

HereditySocial ClassGenomicsHumans

Identifiers

PMID40140606
PMCPMC7617559

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.