Evidence map›Paper›PMID 40140596›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2025

Neurodevelopmental outcomes at age 3 years of preterm infants born at 22-31 weeks' gestation.

Yumi Kono, Satoshi Kusuda, Toshihiko Nishida, Rintaro Mori, Katsuaki Toyoshima, Hatoko Sasaki, Naohiro Yonemoto, Atsushi Uchiyama, Masanori Fujimura, INTACT Study Group

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yumi KonoJichi Medical University, Shimotsuke, Tochigi, Japan. ykono@jichi.ac.jp.ORCID http://orcid.org/0000-0002-0647-7868
Satoshi KusudaNeonatal Research Network of Japan, Shinjuku, Tokyo, Japan.ORCID http://orcid.org/0000-0001-5318-8877
Toshihiko NishidaNational Center for Child Health and Development, Setagaya, Tokyo, Japan.
Rintaro MoriGraduate School of Medicine, Osaka University, Osaka, Osaka, Japan.
Katsuaki ToyoshimaKanagawa Children's Medical Center, Yokohama, Japan.
Hatoko SasakiShizuoka Graduate University of Public Health, Shizuoka, Shizuoka, Japan.ORCID http://orcid.org/0000-0002-5785-0482
Naohiro YonemotoUniversity of Toyama, Toyama, Toyama, Japan.ORCID http://orcid.org/0000-0003-3637-2095
Atsushi UchiyamaTokai University, Isehara, Kanagawa, Japan.
Masanori FujimuraOsaka Women's and Children's Hospital, Izumi, Osaka, Japan.
INTACT Study Group

Funding

Ministry of Health, Labour and Welfare (Ministry of Health, Labour and Welfare, Japan) H22-tokubetsu-shitei-011Ministry of Health, Labour and Welfare (Ministry of Health, Labour and Welfare, Japan) H23-iryou-shitei-008Ministry of Health, Labour and Welfare (Ministry of Health, Labour and Welfare, Japan) H25-iryo-shitei-003Ministry of Health, Labour and Welfare (Ministry of Health, Labour and Welfare, Japan) H27-tokubetsu-shitei-001Ministry of Health, Labour and Welfare (Ministry of Health, Labour and Welfare, Japan) H28-ICT-ippan-001
6 · The paper itself

Abstract

objectiveTo evaluate neurodevelopmental outcomes of very preterm infants by gestational age (GA) using high follow-up rate data. STUDY

designThis secondary analysis included infants born before 32 weeks' gestation in 2012-2014 from the Improvement of NICU practices and Team Approach Cluster randomized controlled Trial (INTACT). The primary outcome was survival without moderate or severe neurodevelopmental impairment (NDI).

resultsAmong 2722 infants, NICU survival rate was 96.5%, ranging 72.1-99.6% at 22-31 weeks. At age three years, 2336 (89.5% of 2610 survivors) were completely assessed; 303 had moderate NDI and 183 had severe NDI. Of these, the proportions of infants surviving without NDI increased with GA; 45.2% at 22 weeks, 57.5% at 23 weeks, 88.1% at 31 weeks.

conclusionAlthough survival without NDI varied by GA, more than half (55.0%, 83/151) of infants born at 22-23 weeks who survived to age three years were without neurodevelopmental sequelae.

Indexed as

Child DevelopmentDevelopmental DisabilitiesInfant, Extremely PrematureInfant, PrematureNeurodevelopmental DisordersChild, PreschoolFemaleFollow-Up StudiesGestational AgeHumansInfant, NewbornIntensive Care Units, NeonatalMaleSurvival Rate

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.