ArticleNature genetics2025
The genome and GeneBank genomics of allotetraploid Nicotiana tabacum provide insights into genome evolution and complex trait regulation.
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Transposable elements and their epigenetic modifications mediate gene expression and subgenome dominance in Brassica carinata.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Chromosome-scale genome of Myriophyllum spicatum unveils the role of allohexaploidy in driving aquatic adaptation and widespread invasion.The Plant journal : for cell and molecular biology · 2026Article
- Gapless and phased genome assembly reveals post-allopolyploidization subgenomic diversification of tobacco centromeres.Genome biology · 2026Article
- Metabolic engineering for tobacco quality improvement: Advances and perspectives.Metabolic engineering communications · 2026Review
- High-quality genome of guar (Cyamopsis tetragonoloba) provides the new insights into the biosynthesis and origination of galactomannans in Fabaceae family.Plant cell reports · 2026Article
- A natural variation within duplicated AsWRKY49-D2 drives the subgenomic functional divergence of homeologs in salt response of allohexaploid oats.Journal of integrative plant biology · 2026Article
- Forward genetic screening of mutants of the wild diploid ancestor Nicotiana sylvestris identifies aspartate oxidase 2 as a key gene for nicotine biosynthesis in cultivated allotetraploid tobacco (Nicotiana tabacum).The Plant journal : for cell and molecular biology · 2026Article
- Root-specific cytokinin catabolism promotes Nicotiana root growth and resilience to drought stress.Planta · 2026Article
- Haldane's law works through X:Autosome incompatibility in Caenorhabditis briggsae/C. nigoni hybrids.Nature communications · 2026Article
- Genomic selection for tar content inFrontiers in plant science · 2026Article
- Construction and optimization of a genomic selection model for total sugar content in tobacco.Frontiers in genetics · 2026Article
- Genome-wide analysis of FATA associated with drought tolerance in tetraploid potato (Frontiers in plant science · 2026Article
- Genome-wide characterization of the sugar transporter protein family identifies candidate genes for bacterial wilt resistance breeding in tobacco.Frontiers in plant science · 2026Article
- NtispH as a key regulator of glandular trichome development and terpenoid metabolism in tobacco (Nicotiana tabacum).Journal of plant research · 2026Article
- A transcriptomic profiling across tissues, developmental stages, and types of Nicotiana tabacum.Scientific data · 2025Article
- GeneCAD: Plant Genome Annotation with a DNA Foundation Model.bioRxiv : the preprint server for biology · 2025Article
- Post-Translational Modifications of TOE3 Regulate Antiviral Defense in Tobacco.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Complexity of schistosome vector bulinine snails in Kenya: Insights from nuclear genome size variation, complete mitochondrial genome sequence, and morphometric analysis.PLoS neglected tropical diseases · 2025Article
- Multilayer perceptron neural network-genetic algorithm for modeling Nicotiana tabacum leaf quality.PloS one · 2025Article
- Genome-wide analysis ofFrontiers in plant science · 2025Article
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27 authors.
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Abstract
Nicotiana tabacum is an allotetraploid hybrid of Nicotiana sylvestris and Nicotiana tomentosiformis and a model organism in genetics. However, features of subgenome evolution, expression coordination, genetic diversity and complex traits regulation of N. tabacum remain unresolved. Here we present chromosome-scale assemblies for all three species, and genotype and phenotypic data for 5,196 N. tabacum germplasms. Chromosome rearrangements and epigenetic modifications are associated with genome evolution and expression coordination following polyploidization. Two subgenomes and genes biased toward one subgenome contributed unevenly to complex trait variation. Using 178 marker-trait associations, a reference genotype-to-phenotype map was built for 39 morphological, developmental and disease resistance traits, and a novel gene regulating leaf width was validated. Signatures of positive and polygenic selection during the process of selective breeding were detected. Our study provides insights into genome evolution, complex traits regulation in allotetraploid N. tabacum and the use of GeneBank-scale resources for advancing genetic and genomic research.
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