ArticleNature2025
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Human T cell engineering via serial delivery of mRNA encapsulated within lipid nanoparticles.Molecular therapy. Nucleic acids · 2026Article
- Canonical and noncanonical autophagy in immunity.Immunity · 2026Review
- High-Content CRISPR Screening: Methods and Applications.MedComm · 2026Review
- Infection control in the brain and the eye.Acta ophthalmologica · 2026Review
- Single-Cell CRISPR: An Efficient Strategy for Decoding Plant Cis-Regulatory Complexity.Plant biotechnology journal · 2026Review
- The impactful role of the HDACs in the regulation of gene expression and as targets for disease therapy.Science advances · 2026Review
- SAICAR Drives T Regulatory Cell Differentiation and FOXP3 Maintenance to Promote Immunotherapy Resistance.Cancer research · 2026Article
- CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.The Journal of clinical investigation · 2026Article
- Histone deacetylases: Function in tumor development and therapeutic prospects (Review).Oncology letters · 2026Review
- Clinical progress of engineered cellular immunotherapies for autoimmunity.Nature biotechnology · 2026Review
- Regulatory T cells in cardiac allograft vasculopathy: from mechanistic insights to clinical tolerance.Frontiers in immunology · 2026Review
- Regulatory T cells in autoimmune diseases: biological mechanisms, clinical translation, and translational challenges.Frontiers in immunology · 2026Review
- Decoding Treg diversity and dysfunction to advance Treg-based therapies in autoimmune and inflammatory diseases.Frontiers in immunology · 2026Review
- Harnessing the immune system: future directions in cancer immunotherapy.Frontiers in immunology · 2026Review
- Regulatory T cell therapy in solid organ transplantation: mechanisms, translational progress, and remaining barriers.Frontiers in immunology · 2026Review
- [Targeting Regulatory T Cells to Remodel Peripheral Immune Tolerance: Research Advances and Future Directions].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Review
- Mitochondria and lysosomes in T cell immunometabolism.Trends in immunology · 2025Review
- Iterative, multimodal, and scalable single-cell profiling for discovery and characterization of signaling regulators.bioRxiv : the preprint server for biology · 2025Article
- Induced regulatory T cells for therapy: targeting RBPJ to enhance stability and function.Signal transduction and targeted therapy · 2025Article
- Single-cell profiling identifies heterogeneity of the immune microenvironment in healthy, primary and lymph node metastatic BC.Frontiers in immunology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Kelvin Y Chen *Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan. chenk@ifrec.osaka-u.ac.jp.ORCID 0000-0002-4406-2604
Tatsuya Kibayashi *Joint Research Chair of Innovative Drug Discovery in Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Ambre GiguelayBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-0417-1109
Mayu HataLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Shunsuke NakajimaJoint Research Chair of Innovative Drug Discovery in Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Norihisa MikamiLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Yusuke TakeshimaLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.ORCID 0000-0001-8312-9309
Kenji IchiyamaLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Ryusuke OmiyaJoint Research Chair of Innovative Drug Discovery in Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Leif S LudwigBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-2916-2164
Kunihiro HattoriJoint Research Chair of Innovative Drug Discovery in Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Shimon SakaguchiLaboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan. shimon@ifrec.osaka-u.ac.jp.ORCID 0000-0001-8265-6094
Funding
Japan Agency for Medical Research and DevelopmentJapan Society for Promotion of ScienceJapan Society for the Promotion of Science
Abstract
Regulatory T (T
Indexed as
CRISPR-Cas SystemsForkhead Transcription FactorsGenetic TechniquesGenome, HumanT-Lymphocytes, RegulatoryAcetylationAnimalsCell DifferentiationClustered Regularly Interspaced Short Palindromic RepeatsFemaleGene Expression RegulationGraft vs Host DiseaseHistone Deacetylase 3Histone DeacetylasesHistonesHumansForkhead Transcription FactorsFOXP3 protein, humanHistone Deacetylase 3Histone DeacetylasesHistones
Identifiers
PMID
40140585What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.