ArticleNature2025
The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Time matters: circadian genetics and the molecular logic of human health and disease.Nature reviews. Genetics · 2026Review
- From phenomenon to mechanism in the circadian clock of Synechococcus elongatus.Npj biological timing and sleep · 2026Review
- Cyanobacterial Circadian Clock: Molecular Mechanisms and Physiological Outputs.Plants (Basel, Switzerland) · 2026Review
- Insights into the function and structure of the R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) chaperone complex.Cell stress & chaperones · 2026Review
- The suprachiasmatic nucleus: a central pacemaker for temporal coordination of energy metabolic homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Intracellular potassium levels orchestrate circadian rhythmicity and cell division.Nature communications · 2026Article
- Noncanonical clock regulators control stress responses in digestive diseases.Trends in endocrinology and metabolism: TEM · 2026Review
- Reconsidering mammalian circadian organization.Neurobiology of sleep and circadian rhythms · 2026Article
- Time after time - circadian clocks through the lens of oscillator theory.FEBS letters · 2026Review
- Mechanism and reconstitution of circadian transcription in cyanobacteria.Nature structural & molecular biology · 2026Article
- The Centriole Biogenesis Cycle: Temporal Mechanisms, Autonomy and Coupling to the Cell Cycle and Other Cellular Clocks.Advances in experimental medicine and biology · 2026Review
- Temperature compensation of the Arabidopsis circadian clock.Npj biological timing and sleep · 2025Review
- An intron-based timer for circadian rhythms.bioRxiv : the preprint server for biology · 2025Article
- Galactose-modified small molecule modulator targets RORα to enhance circadian rhythm and alleviate periodontitis-associated alveolar bone loss.Bone research · 2025Article
- Circadian Biology in Parasites: Beyond Known Mechanisms.Annual review of microbiology · 2025Review
- Site- and cell-type-specific miRNA and mRNA genes and networks across the cortex, striatum, and hypothalamus.Communications biology · 2025Article
- The cyanobacterial circadian clock.Npj biological timing and sleep · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
24 authors.
Meimei Liao *National Institute of Biological Sciences, Beijing, China.ORCID 0000-0003-4334-5861
Yanqin Liu *National Institute of Biological Sciences, Beijing, China.
Zhancong Xu *National Institute of Biological Sciences, Beijing, China.
Mingxu FangCenter for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-1595-8046
Ziqing YuNational Institute of Biological Sciences, Beijing, China.
Yufan CuiNational Institute of Biological Sciences, Beijing, China.
Zhengda SunNational Institute of Biological Sciences, Beijing, China.
Ran HuoNational Institute of Biological Sciences, Beijing, China.
Jieyu YangNational Institute of Biological Sciences, Beijing, China.
Fusheng HuangCollege of Biological Sciences, China Agricultural University, Beijing, China.
Mingming LiuState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Qin ZhouInstitute of Health Sciences and Technology, Institutes of Physical Science and Information Technology, Anhui University, Hefei, China.
Xiaocui SongNational Institute of Biological Sciences, Beijing, China.
Hui HanNational Institute of Biological Sciences, Beijing, China.
She ChenNational Institute of Biological Sciences, Beijing, China.ORCID 0000-0002-0830-3263
Xiaodong XuState Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng, China.
Ximing QinInstitute of Health Sciences and Technology, Institutes of Physical Science and Information Technology, Anhui University, Hefei, China.
Qun HeCollege of Biological Sciences, China Agricultural University, Beijing, China.
Dapeng JuDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.ORCID 0000-0003-1798-1362
Tao WangNational Institute of Biological Sciences, Beijing, China.
Nirav ThakkarDepartment of Biology and Center for Biological Clocks Research, Texas A&M University, College Station, TX, USA.
Paul E HardinDepartment of Biology and Center for Biological Clocks Research, Texas A&M University, College Station, TX, USA.
Susan S GoldenCenter for Circadian Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-4264-7019
Eric Erquan ZhangNational Institute of Biological Sciences, Beijing, China. zhangerquan@nibs.ac.cn.ORCID 0000-0002-4472-7493
Funding
Undergraduate Summer Research Experience: Molecular and cellular mechanisms of circadian timekeeping in a prokaryote modelR35GM118290 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDEN, SUSAN S · 2016 to 2025
$6.7MMechanisms of Circadian RepressionR01GM124617 · NIGMS · TEXAS A&M UNIVERSITY · PI PAUL E HARDIN, Christine Merlin · 2017 to 2026
$2.7MNIGMS NIH HHS R01 GM124617NIGMS NIH HHS R35 GM118290
Abstract
The eukaryotic circadian clock keeps time by using a transcription-translation feedback loop, which exhibits an architecture that is conserved across a diverse range of organisms, including fungi, plants and animals
Indexed as
Adenosine TriphosphatasesCircadian ClocksEukaryotaAdenosine TriphosphateAnimalsATPases Associated with Diverse Cellular ActivitiesCircadian RhythmCLOCK ProteinsDrosophila melanogasterFemaleHumansHydrolysisMaleMiceMutationAdenosine TriphosphatasesAdenosine TriphosphateATPases Associated with Diverse Cellular ActivitiesCLOCK Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.