Evidence map›Paper›PMID 40140576›Full record

ArticleNature2025

Connectome-driven neural inventory of a complete visual system.

Aljoscha Nern, Frank Loesche, Shin-Ya Takemura, Laura E Burnett, Marisa Dreher, Eyal Gruntman, Judith Hoeller, Gary B Huang, Michał Januszewski, Nathan C Klapoetke and 61 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
  2. Distribution and voltage dependence of ion channels shape single-neuron computations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Regulatory logic of neuronal differentiation in theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Imprecision in Vision: Lessons From Neural Circuits in the Fly.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  15. Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  16. Article
  17. Review
  18. Article
  19. Visual input drives diverse ER calcium signals in neuronsbioRxiv : the preprint server for biology · 2025
    Article
  20. Population Morphology Implies a Common Developmental Blueprint forbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

71 authors.

Aljoscha NernJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-3822-489X
Frank Loesche *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-7780-6438
Shin-Ya Takemura *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0003-2400-6426
Laura E Burnett *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Marisa Dreher *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Eyal Gruntman *University of Toronto, Scarborough, Ontario, Canada.
Judith Hoeller *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Gary B Huang *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Michał Januszewski *Google Research, Google, Zurich, Switzerland.ORCID 0000-0002-3480-2744
Nathan C Klapoetke *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Sanna Koskela *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Kit D Longden *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-7686-6447
Zhiyuan Lu *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Stephan Preibisch *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-0276-494X
Wei Qiu *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Edward M Rogers *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Pavithraa Seenivasan *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Arthur Zhao *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0003-2869-4393
John BogovicJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-4829-9457
Brandon S CaninoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Jody ClementsJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0003-3932-8188
Michael CookJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Samantha Finley-MayJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Miriam A FlynnJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Imran HameedJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Alexandra M C FragniereMRC Laboratory of Molecular Biology, Cambridge, UK.
Kenneth J HayworthJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Gary Patrick HopkinsJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Philip M HubbardJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-6746-5035
William T KatzJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-9417-6212
Julie KovalyakJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Shirley A LauchieJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Meghan LeonardJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Alanna LohffJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Charli A MaldonadoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Caroline MooneyJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Nneoma OkeomaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Donald J OlbrisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0009-0008-8581-0550
Christopher OrdishJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Tyler PatersonJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Emily M PhillipsJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Tobias PietzschJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Jennifer Rivas SalinasJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Patricia K RivlinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-3435-1955
Philipp SchlegelMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-5633-1314
Ashley L ScottJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Louis A ScuderiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Satoko TakemuraJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Iris TalebiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Alexander ThomsonJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0001-8462-2090
Eric T TrautmanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0001-8588-0569
Lowell UmayamJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Claire WalshJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
John J WalshJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
C Shan XuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-8564-7836
Emily A YakalJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Tansy YangJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0003-1131-0410
Ting ZhaoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Jan FunkeJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0003-4388-7783
Reed GeorgeJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Harald F HessJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0003-3000-1533
Gregory S X E JefferisMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-0587-9355
Christopher KnechtJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Wyatt KorffJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0001-8396-1533
Stephen M PlazaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Sandro RomaniJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-4727-4207
Stephan SaalfeldJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-4106-1761
Louis K SchefferJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-3289-6564
Stuart BergJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. bergs@janelia.hhmi.org.ORCID 0000-0002-0766-0488
Gerald M RubinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. rubing@janelia.hhmi.org.ORCID 0000-0001-8762-8703
Michael B ReiserJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. reiserm@janelia.hhmi.org.ORCID 0000-0002-4108-4517

Funding

Fluorender: An Imaging Tool for Visualization and Analysis of Confocal Data as ApR01GM098151 · NIGMS · UNIVERSITY OF UTAH · PI HANSEN, CHARLES · 2011 to 2014
$1.2M
NIGMS NIH HHS R01 GM098151Wellcome Trust
6 · The paper itself

Abstract

Vision provides animals with detailed information about their surroundings and conveys diverse features such as colour, form and movement across the visual scene. Computing these parallel spatial features requires a large and diverse network of neurons. Consequently, from flies to humans, visual regions in the brain constitute half its volume. These visual regions often have marked structure-function relationships, with neurons organized along spatial maps and with shapes that directly relate to their roles in visual processing. More than a century of anatomical studies have catalogued in detail cell types in fly visual systems

Indexed as

ConnectomeDrosophila melanogasterOptic Lobe, NonmammalianVisual PathwaysAnimalsMaleNeuronsNeurotransmitter AgentsSynapsesNeurotransmitter Agents

Identifiers

PMID40140576
PMCPMC12119369

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.