ArticleNature2025
Plasticity of the mammalian integrated stress response.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Integrative RNA-Seq Analysis Reveals Stress Type-Dependent lncRNA-Centered Co-Expression Networks Across Human Cellular Stress Contexts.International journal of molecular sciences · 2026Article
- Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8.Experimental & molecular medicine · 2026Article
- Oocyte-specific knockout of eIF2B subunits causes apoptosis of mouse oocytes within the early growing follicles via DNA damage and mitochondrial dysfunction.Cell death & disease · 2026Article
- Elongationless start-stop elements are stress-resilient translation gates that are more repressive than uTranslons.Nucleic acids research · 2026Article
- Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution.Nature cell biology · 2026Article
- The integrated developmental stress response (ISR-DASR) shift reveals a functional transition from cellular to stem cell organismal adaptation.Scientific reports · 2026Article
- Heavy water labeling reveals metabolic flexibility of amino acid and polyamine pathways in mammalian cells.Communications chemistry · 2026Article
- Review
- Unfolding Resilience: Molecular Integration of the Integrated Stress Response and Mitochondrial UPR in Skeletal Muscle Homeostasis.Muscles (Basel, Switzerland) · 2026Review
- Mitochondria-targeted metformin analogs activate the ER stress-unfolded protein response pathway to drive apoptosis in pancreatic cancer.Cell death & disease · 2026Article
- CHOP promotes the transition to chronic integrated stress response signaling with suppression of hepatocyte identity.bioRxiv : the preprint server for biology · 2026Article
- Multi-Organelle Stress-Induced Paraptosis by a ROS-Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ATF4: Orchestrating Cellular Stress Adaptation, Metabolism, and Immune Regulation in Health and Disease.International journal of molecular sciences · 2026Review
- [ModifiedNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- RK-33 inhibits the OC43 coronavirus and induces stress granules via DDX3X-independent mechanisms.RNA (New York, N.Y.) · 2026Article
- Therapy as a State-Generator: Dynamic Phenotypic Landscapes and Adaptive Stress Circuits in Chemotherapy Resistance of Breast Cancer.Antioxidants (Basel, Switzerland) · 2026Review
- The Janus framework of the integrated stress response: from homeostasis to maladaptation.Life science alliance · 2026Review
- A disease-causing isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress response.The Journal of biological chemistry · 2026Article
- Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine-dependent Tumor Subset Under Metabolic Relationships With CAFs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Chien-Wen Chen *Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-1214-4058
David Papadopoli *Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.
Krzysztof J Szkop *Department of Oncology-Pathology, Karolinska Institute, Science of Life Laboratory, Solna, Sweden.
Bo-Jhih GuanDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Mohammed AlzahraniDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0001-7291-5275
Jing WuDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID 0009-0000-5199-1199
Raul JobavaDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Mais M AsrafDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Dawid KrokowskiDepartment of Molecular Biology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland.
Anastasios VourekasDepartment of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA.ORCID 0000-0002-1850-5635
William C MerrickDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.
Anton A KomarDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.
Antonis E KoromilasLady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.ORCID 0000-0003-1972-0799
Myriam GorospeLaboratory of Genetics and Genomics, National Institute of Aging Intramural Research Program, NIH, Baltimore, MD, USA.ORCID 0000-0001-5439-3434
Matthew J PayeaLaboratory of Genetics and Genomics, National Institute of Aging Intramural Research Program, NIH, Baltimore, MD, USA.ORCID 0000-0002-1960-4563
Fangfang WangDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.
Benjamin L L ClaytonDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0001-9552-404X
Paul J TesarDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0003-1532-3155
Ashleigh SchafferDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-1164-697X
Alexander MironDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Ilya BedermanDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-1909-5746
Eckhard JankowskyDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.
Christine VogelDepartment of Biology, New York University, New York, NY, USA.ORCID 0000-0002-2856-3118
Leoš Shivaya ValášekLaboratory of Regulation of Gene Expression, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.ORCID 0000-0001-8123-8667
Jonathan D DinmanDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID 0000-0002-2402-9698
Youwei ZhangDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0003-0011-7922
Boaz TiroshDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.
Ola LarssonDepartment of Oncology-Pathology, Karolinska Institute, Science of Life Laboratory, Solna, Sweden. ola.larsson@ki.se.ORCID 0000-0003-1412-1308
Ivan TopisirovicLady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada. ivan.topisirovic@mcgill.ca.ORCID 0000-0002-5510-9762
Maria HatzoglouDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA. mxh8@case.edu.ORCID 0000-0003-2037-1231
Funding
TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3MRegulation of Gene Expression During StressR01DK053307 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI HATZOGLOU, MARIA · 1998 to 2021
$9.6MTranslational Control by NutrientsR01DK060596 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI MARIA HATZOGLOU · 2002 to 2026
$6.3MTranslational Control by Osmotically Active SolutesR37DK060596 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI HATZOGLOU, MARIA · 2011 to 2020
$5.3MModulating Glial Fate and Function in Development and DiseaseR35NS116842 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Paul Joseph Tesar · 2020 to 2026
$5.3MViral Noncoding RNAs and Cell TransformationR01CA259386 · NCI · YALE UNIVERSITY · PI JOAN A. STEITZ · 2022 to 2026
$3.2MTargeting DNA repair in KRAS mutated lung cancer by chemical screeningR01CA230453 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI ZHANG, YOU-WEI · 2019 to 2023
$2.4MBridges to the Baccalaureate Research Training Program at Cuyahoga Community CollegeT34GM137792 · NIGMS · CUYAHOGA COMMUNITY COLLEGE · PI GATICA, JORGE E, HATZOGLOU, MARIA · 2020 to 2024
$1.8MPost-transcriptional Regulation Of Proliferative and Stress Response GenesZ01AG000511 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM NONE · 1998 to 2008
$1.6MSupplement: 53BP1 regulates genome biology and cellular physiology through liquid phase separationR01GM148662 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI ZHANG, YOU-WEI · 2023 to 2025
$1.4MeIF2A in translational controlR01GM128981 · NIGMS · CLEVELAND STATE UNIVERSITY · PI KOMAR, ANTON A. · 2020 to 2023
$1.2MIntramural NIH HHS Z01 AG000511NCI NIH HHS P30 CA043703NCI NIH HHS R01 CA230453NCI NIH HHS R01 CA259386NIDDK NIH HHS R01 DK053307NIDDK NIH HHS R01 DK060596NIDDK NIH HHS R37 DK060596NIGMS NIH HHS R01 GM128981NIGMS NIH HHS R01 GM148662NIGMS NIH HHS T34 GM137792NINDS NIH HHS R35 NS116842
Abstract
An increased level of phosphorylation of eukaryotic translation initiation factor 2 subunit-α (eIF2α, encoded by EIF2S1; eIF2α-p) coupled with decreased guanine nucleotide exchange activity of eIF2B is a hallmark of the 'canonical' integrated stress response (c-ISR)
Indexed as
Eukaryotic Initiation FactorsStress, PhysiologicalActivating Transcription Factor 4AnimalsEnergy MetabolismEukaryotic Initiation Factor-2Eukaryotic Initiation Factor-2BEukaryotic Initiation Factor-4EHumansMicePhosphorylationProtein BiosynthesisRNA, MessengerRNA StabilityActivating Transcription Factor 4ATF4 protein, humanEukaryotic Initiation Factor-2Eukaryotic Initiation Factor-2BEukaryotic Initiation Factor-4EEukaryotic Initiation FactorsRNA, Messenger
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.