ArticleNature2025
Changes in neurotensin signalling drive hedonic devaluation in obesity.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader-Willi syndrome.The Journal of physiology · 2026Article
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- New perspective on acupuncture treatment for obesity: mechanisms in the brain based on multidimensional neural circuits.American journal of translational research · 2026Review
- Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.Brain research · 2026Review
- Article
- Disrupting the Gut-Brain Axis: How Artificial Sweeteners Rewire Microbiota and Reward Pathways.International journal of molecular sciences · 2025Review
- Influence of the neurotensin signaling system on feeding and satiety.Neuropharmacology · 2025Review
- Hijacked Brain in Modern Obesity: Cue, Habit, Addiction, Emotion, and Restraint as Targets for Personalized Digital Therapy and Electroceuticals.Journal of obesity & metabolic syndrome · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Neta Gazit Shimoni *Department of Neuroscience and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
Amanda J Tose *Department of Neuroscience and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.ORCID 0000-0002-3372-9645
Charlotte SengBrain Research Institute, Faculties of Medicine and Science, University of Zurich, Zürich, Switzerland.
Yihan JinDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Davis, CA, USA.
Tamás LukacsovichBrain Research Institute, Faculties of Medicine and Science, University of Zurich, Zürich, Switzerland.
Hongbin YangDepartment of Neurobiology and Department of Affiliated Mental Health Center of Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China.ORCID 0000-0001-8574-1542
Jeroen P H VerharenDepartment of Neuroscience and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
Christine LiuDepartment of Neuroscience and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.ORCID 0000-0002-8054-1039
Michael TaniosDepartment of Neuroscience and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.ORCID 0009-0007-4706-959X
Eric HuDepartment of Neuroscience and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.ORCID 0000-0002-4310-3355
Jonathan ReadDepartment of Neuroscience and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
Lilly W TangDepartment of Neuroscience and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.ORCID 0000-0001-5151-9177
Byung Kook LimDivision of Biological Sciences, University of California San Diego, San Diego, CA, USA.ORCID 0000-0002-3766-5415
Lin TianDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Davis, CA, USA.ORCID 0000-0001-7012-6926
Csaba FöldyBrain Research Institute, Faculties of Medicine and Science, University of Zurich, Zürich, Switzerland.ORCID 0000-0001-8709-8490
Stephan LammelDepartment of Neuroscience and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA. lammel@berkeley.edu.ORCID 0000-0002-3350-3208
Funding
UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RICHARD H KRAMER · 1985 to 2026
$16.4MInput-specific mechanisms of drug-evoked synaptic plasticity in the ventral tegmental areaR01DA042889 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Stephan Lammel · 2017 to 2026
$4.0MNext generation all-optical toolkits for functional analysis of neuropeptide dynamics in neural circuitsU01NS113295 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANGHART, MATTHEW R., SABATINI, BERNARDO L · 2019 to 2022
$3.7MMultiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolutionU01NS120820 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN, VONZASTROW, MARK E · 2021 to 2024
$3.5MGenetically encoded indicators for large-scale sensing of neuromodulatory signaling in behaving animalsU01NS103522 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NIMMERJAHN, AXEL, TIAN, LIN · 2017 to 2019
$2.9MRole of Glutamatergic Neurons in External Globus Pallidus in the Behavioral Deficits in Animal Models of Progressive Dopamine DepletionR01NS121231 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEUTGEB, STEFAN, LIM, BYUNGKOOK · 2021 to 2025
$2.5MDissecting the role of ventral pallidal circuitry in cocaine seeking after the withdrawalR01DA049787 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIM, BYUNGKOOK · 2020 to 2024
$1.8MNeuropeptidergic mechanisms underlying hedonic feeding behaviorR01DK140665 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Stephan Lammel · 2025 to 2026
$1.3MA Zeiss LSM 710 confocal microscope for the Biological Imaging Facility at the US10RR026866 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUZIN, STEVEN EARL · 2010 to 2010
$419kNCRR NIH HHS S10 RR026866NEI NIH HHS P30 EY003176NIDA NIH HHS R01 DA042889NIDA NIH HHS R01 DA049787NIDDK NIH HHS R01 DK140665NINDS NIH HHS R01 NS121231NINDS NIH HHS U01 NS103522NINDS NIH HHS U01 NS113295NINDS NIH HHS U01 NS120820
Abstract
Calorie-rich foods, particularly those that are high in fat and sugar, evoke pleasure in both humans and animals
Indexed as
Feeding BehaviorNeurotensinObesityPleasureSignal TransductionAnimalsDiet, High-FatMaleMiceMice, Inbred C57BLNeuronsNucleus AccumbensOptogeneticsReceptors, NeurotensinVentral Tegmental AreaNeurotensinReceptors, Neurotensin
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.