Evidence map›Paper›PMID 40140570›Full record

ArticleNature2025

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures.

Anish Kumar Mondal, Elisa Carrillo, Vasanthi Jayaraman, Edward C Twomey

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Temperature and intrinsic CaNature structural & molecular biology · 2026
    Article
  7. Article
  8. Molecular basis for ligand-gating of the human GluD1 receptor.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Activation of kainate receptor GluK2-Neto2 complex.Nature structural & molecular biology · 2025
    Article
  14. Review
  15. Article
  16. Structure and gating of kainate receptors.Frontiers in pharmacology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Anish Kumar MondalDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elisa CarrilloCenter for Membrane Biology, Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX, USA.
Vasanthi JayaramanCenter for Membrane Biology, Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX, USA. Vasanthi.Jayaraman@uth.tmc.edu.ORCID 0000-0002-2686-7310
Edward C TwomeyDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Twomey@jhmi.edu.ORCID 0000-0002-1855-1586

Funding

Dynamics Of Ligand Gated Ion ChannelsR35GM122528 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Vasanthi Jayaraman · 2017 to 2026
$6.2M
Ligand Gated Ion Channels Across Time and SpaceR35GM154904 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Edward C Twomey · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM122528NIGMS NIH HHS R35 GM154904
6 · The paper itself

Abstract

Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that mediate most excitatory neurotransmission

Indexed as

Glutamic AcidIon Channel GatingReceptors, AMPAAnimalsCryoelectron MicroscopyHumansModels, MolecularProtein MultimerizationTemperatureGlutamic AcidReceptors, AMPA

Identifiers

PMID40140570
PMCPMC12074995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.