Evidence map›Paper›PMID 40140564›Full record

ArticleNature2025

A human brain map of mitochondrial respiratory capacity and diversity.

Eugene V Mosharov, Ayelet M Rosenberg, Anna S Monzel, Corey A Osto, Linsey Stiles, Gorazd B Rosoklija, Andrew J Dwork, Snehal Bindra, Alex Junker, Ya Zhang and 12 more

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed.

  1. Review
  2. Mitochondrial molecular diversity in the brain.Current opinion in neurobiology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Dose dependence and neurovascular mechanisms of the fMRI response to pulsed photobiomodulation in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. First Total-Body Kinetics Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  13. Metabolism-weighted brain connectome reveals synaptic integration and vulnerability to neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Eugene V MosharovDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-0229-7114
Ayelet M Rosenberg *Department of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Anna S Monzel *Department of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Corey A OstoDepartment of Medicine, Endocrinology, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Linsey StilesDepartment of Medicine, Endocrinology, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-1514-458X
Gorazd B RosoklijaNew York State Psychiatric Institute, New York, NY, USA.
Andrew J DworkNew York State Psychiatric Institute, New York, NY, USA.
Snehal BindraDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Alex JunkerDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Ya ZhangCenter for Translational and Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
Masashi FujitaCenter for Translational and Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
Madeline B MarianiNew York State Psychiatric Institute, New York, NY, USA.ORCID 0009-0006-8183-1173
Mihran BakalianNew York State Psychiatric Institute, New York, NY, USA.
David SulzerDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-7632-0439
Philip L De JagerCenter for Translational and Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-8057-2505
Vilas MenonCenter for Translational and Computational Neuroimmunology, Neuroimmunology Division, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-4096-8601
Orian S ShirihaiDepartment of Medicine, Endocrinology, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-8466-3431
J John MannNew York State Psychiatric Institute, New York, NY, USA.
Mark D UnderwoodNew York State Psychiatric Institute, New York, NY, USA.
Maura BoldriniNew York State Psychiatric Institute, New York, NY, USA.ORCID 0000-0003-3574-7641
Michel Thiebaut de SchottenBrain Connectivity and Behaviour Laboratory, Paris, France. michel.thiebaut@gmail.com.ORCID 0000-0002-0329-1814
Martin PicardDepartment of Psychiatry, Divisions of Molecular Therapeutics and Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, USA. martin.picard@columbia.edu.ORCID 0000-0003-2835-0478

Funding

The Dopamine Synapse and Associative LearningR01DA007418 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David Sulzer · 1999 to 2026
$9.4M
Deconstructing and modeling the single cell architecture of the Alzheimer brainRF1AG057473 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2017 to 2018
$4.0M
Mitochondrial Energetics, Circuits and Cognitive Decline in the Aging Human BrainRF1AG076821 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2022 to 2022
$2.4M
Mapping Mitochondrial Diversity in the Aging Brain and Immune SystemR01AG086764 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Martin Picard · 2024 to 2026
$2.1M
Mitochondrial Energetics, Circuits and Cognitive Decline in the Aging Human BrainR01AG076821 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Martin Picard · 2025 to 2026
$1.6M
NIA NIH HHS R01 AG076821NIA NIH HHS R01 AG086764NIA NIH HHS RF1 AG057473NIA NIH HHS RF1 AG076821NIDA NIH HHS R01 DA007418
6 · The paper itself

Abstract

Mitochondrial oxidative phosphorylation (OXPHOS) powers brain activity

Indexed as

BrainBrain MappingMitochondriaAdultAgedCell RespirationDNA, MitochondrialFemaleGray MatterHumansMaleMiddle AgedNeuroimagingOxidative PhosphorylationPhenotypeWhite MatterDNA, Mitochondrial

Identifiers

PMID40140564
PMCPMC12770858

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.