Evidence map›Paper›PMID 40140493›Full record

ArticleScientific reports2025

Regional quantification of metabolic liver function using hyperpolarized [1-

Uffe Kjaergaard, Andrea Lund, Mohsen Redda, Mattias Hedegaard Kristensen, Malene Aastrup, Nikolaj Bøgh, Kim Sivesgaard, Michael A Ohliger, Daniel B Vigneron, Lotte Bonde Bertelsen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Proof-of-Concept Study of Hyperpolarized [1-Radiology. Imaging cancer · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Uffe KjaergaardMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. uffe@clin.au.dk.
Andrea LundDepartment of Surgery, Section for HPB Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Mohsen ReddaMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Mattias Hedegaard KristensenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Malene AastrupMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Nikolaj BøghMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Kim SivesgaardDepartment of Radiology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Lotte Bonde BertelsenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Aage Kristian Olsen AlstrupDepartment of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark.
Esben Søvsø Szocska HansenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Frank Viborg MortensenDepartment of Surgery, Section for HPB Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.
Christoffer LaustsenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Kræftens Bekæmpelse R279-A16251NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

Assessment of liver function is essential before partial hepatectomy to predict the risk of post hepatectomy liver failure, a severe and life-threatening complication. Traditional methods have focused on expected future liver remnant (FLR) volume estimation. However, liver volume does not always correlate with function. We suggest that metabolism might be a better surrogate for function than volume. Therefore, we aimed to investigate the metabolic changes in a porcine model of partial portal vein ligation (PVL) using hyperpolarized magnetic resonance imaging (HP-MRI). Specifically, we sought to quantify and compare the pyruvate metabolism in the FLR and the deportalized liver (DL).Six pigs underwent PVL. HP-MRI with [1-

Indexed as

LiverMagnetic Resonance ImagingPyruvic AcidAnimalsCarbon IsotopesGlycolysisHepatectomyPortal VeinSwineCarbon-13Carbon IsotopesPyruvic AcidAlanine aminotransferase (ALT)Gadoxetate-enhanced imagingHepatic functionHyperpolarizedLactate dehydrogenase (LDH)Liver regenerationMagnetic resonance imagingMetabolic imagingPortal vein ligationPost-hepatectomy liver failure (PHLF)Translational

Identifiers

PMID40140493
PMCPMC11947255

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.