Evidence map›Paper›PMID 40140479›Full record

ArticleScientific reports2025

Brain functional and structural alteration following acute carbon monoxide poisoning contribute to delayed neurological sequelae.

Yanli Zhang, Tianhong Wang, Chaoning Zhou, Shuaiwen Wang, Zhaodong Liu, Junqiang Lei

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yanli ZhangDeparment of Radiology, The First Hospital of Lanzhou University, No. 1, Donggangxi Road, Chengguan District, Lanzhou, 730000, Gansu, China.
Tianhong WangDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, China.
Chaoning ZhouDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, China.
Shuaiwen WangDeparment of Radiology, The First Hospital of Lanzhou University, No. 1, Donggangxi Road, Chengguan District, Lanzhou, 730000, Gansu, China.
Zhaodong LiuDepartment of Neurology, The First Hospital of Lanzhou University, Lanzhou, China.
Junqiang LeiDeparment of Radiology, The First Hospital of Lanzhou University, No. 1, Donggangxi Road, Chengguan District, Lanzhou, 730000, Gansu, China. leijq2011@126.com.

Funding

National Natural Science Foundation of China 82160930Research Project of Gansu provincial administration of traditional Chinese medicine GZKZ-2021-8Technology plan project of Lanzhou city 2020-ZD-71
6 · The paper itself

Abstract

purposeTo investigate whether altered functional activity, functional connectivity (FC), and structural connectivity (SC) following acute carbon monoxide (CO) poisoning contribute to delayed neurological sequelae (DNS) occurrence.

methodsBinary degree centrality (DC) and seed-based FC were investigated in 18 patients with DNS, 26 patients without DNS, and 30 healthy controls. Duration of CO exposure and coma severity indices-related fibers was detected by connectometry analysis and the identified fiber tracts were tracked and their SC alteration was quantify by fractional anisotropy (FA).

resultsAcute CO exposure induced DC change in the prefrontal cortex (PFC), visual cortex, primary sensory cortex, and anterior cerebellum, and FC alteration between the right fusiform gyrus (seed) and bilateral PFC and left inferior occipital gyrus (Gaussian random field corrected, P < 0.05). Poisoning severity indices-related WM fibers consisted of corpus callosum and some association and projection fibers (false discovery rate corrected, P < 0.05). Only altered DC in the right fusiform gyrus and right postcentral gyrus and reduced FC of the PFC could identify DNS occurrence (P < 0.05).

conclusionsThe functional abnormalities in the visual- and sensory- cortex and PFC subsequent to acute CO poisoning represent one of the potential neural mechanisms underlying the occurrence of DNS.

Indexed as

BrainCarbon Monoxide PoisoningAdultCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedCarbon monoxide poisoningDegree centralityDelayed neurological sequelaeFractional anisotropyFunctional connectivity

Identifiers

PMID40140479
PMCPMC11947078

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