Evidence map›Paper›PMID 40140427›Full record

ArticleScientific reports2025

Loss of fatty acid-binding protein 7 promotes B16F10 melanoma metastasis.

Tunyanat Wannakul, Hirofumi Miyazaki, Motoko Maekawa, Yoshiteru Kagawa, Yui Yamamoto, Yuji Owada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tunyanat WannakulDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, 9F Building #5, 2-1 Seiryo-Machi, Aoba-ku, Sendai, 980-8575, Japan.
Hirofumi MiyazakiDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, 9F Building #5, 2-1 Seiryo-Machi, Aoba-ku, Sendai, 980-8575, Japan. hmiyazaki@med.tohoku.ac.jp.
Motoko MaekawaDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, 9F Building #5, 2-1 Seiryo-Machi, Aoba-ku, Sendai, 980-8575, Japan.
Yoshiteru KagawaDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, 9F Building #5, 2-1 Seiryo-Machi, Aoba-ku, Sendai, 980-8575, Japan.
Yui YamamotoDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, 9F Building #5, 2-1 Seiryo-Machi, Aoba-ku, Sendai, 980-8575, Japan.
Yuji OwadaDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, 9F Building #5, 2-1 Seiryo-Machi, Aoba-ku, Sendai, 980-8575, Japan.

Funding

Japan Society for the Promotion of Science 22K19724, 22H03526
6 · The paper itself

Abstract

Melanoma possesses the characteristic phenotypic plasticity, enhancing its metastatic formation and drug resistance. Lipid and fatty acid metabolism are usually altered to support melanoma progression and can be targeted for therapeutic development. Fatty acid binding protein 7 (FABP7) is highly expressed in melanomas and is shown to support its proliferation, migration, and invasion, but the mechanisms remain unclear. Our study aimed to link FABP7 to lipid metabolism and phenotypic shift in melanomas. We established the Fabp7-knockout (KO) B16F10 melanoma cells, which showed an enhanced invasion through matrix-coated membrane, without significant change in proliferation. Similar outcomes were obtained when using RNA interference targeting FABP7. Fabp7-KO cells injected into mice exhibited slower primary tumor growth, but formed higher metastatic foci count in the lungs. We also discovered a higher saturation in overall lipids, phosphatidylcholines, and triacylglycerols. We observed transcriptional shifts toward the invasive MITF

Indexed as

Fatty Acid-Binding Protein 7Melanoma, ExperimentalAnimalsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticLipid MetabolismMiceNeoplasm InvasivenessNeoplasm MetastasisFatty Acid-Binding Protein 7AdaptationFatty acid-binding protein 7Lipid metabolismMelanomaNeoplasm metastasisPhysiological

Identifiers

PMID40140427
PMCPMC11947267

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.