ArticleNature communications2025
Gamma entrainment induced by deep brain stimulation as a biomarker for motor improvement with neuromodulation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Adaptive deep brain stimulation for dynamic gait control in Parkinson's disease: a randomized feasibility trial.Nature medicine · 2026Trial
- Cortico-basal oscillations index naturalistic movements during deep brain stimulation.Brain : a journal of neurology · 2026Article
- Stimulation and Medication Effects on Subthalamic Nucleus Beta-Band Power in Parkinson's Disease: Implications for Adaptive Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.Nature medicine · 2026Article
- Acute and Chronic Local Field Potential Recordings in Dystonia-A Systematic Review.Movement disorders clinical practice · 2026Review
- Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states.bioRxiv : the preprint server for biology · 2026Article
- Gamma entrainment as a functional target in deep brain stimulation.Neural regeneration research · 2026Article
- DBSsync: combining intracranial and multimodal data to investigate new biomarkers in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Entrainment of cortical gamma oscillations predicts improved bradykinesia and dyskinesia in Parkinson's disease.medRxiv : the preprint server for health sciences · 2026Article
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Driving motor cortex oscillations restores plasticity and improves bradykinesia features in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Cognitive trajectories in Parkinson's disease patients, a review on the impact of subthalamic deep brain stimulation (STN-DBS) and emerging adaptive strategies.Translational psychiatry · 2026Review
- Spatial signature of low-frequency network changes accounts for pallidal stimulation outcome in cervical dystonia.EBioMedicine · 2026Article
- Target-specific modulation of cortical narrowband gamma by basal ganglia nuclei: a case report.Frontiers in human neuroscience · 2026Article
- Finely Tuned Gamma Oscillations in the Globus Pallidus Internus in Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Local field potential biomarkers for adaptive deep brain stimulation in Parkinson's disease: A scoping review.Surgical neurology international · 2026Review
- Chronic adaptive deep brain stimulation for Parkinson's disease: clinical outcomes and programming strategies.NPJ Parkinson's disease · 2025Article
- Oscillatory dynamics in isolated dystonia: five hundred hours of chronic invasive multisite motor network recordings.Journal of neurophysiology · 2025Article
- Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain-Sense Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- EEG activity over ipsilateral and contralateral M1 during simple and complex hand tasks: variations with motor learning.Frontiers in neuroscience · 2025Article
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9 authors.
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Abstract
Finely tuned gamma (FTG) oscillations from the subthalamic nucleus (STN) and cortex in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS) are often associated with dyskinesia. Recently it was shown that DBS entrains gamma activity at 1:2 of the stimulation frequency; however, the functional role of this signal is not yet fully understood. We recorded local field potentials from the STN in 19 chronically implanted PD patients on dopaminergic medication during DBS, at rest, and during repetitive movements. Here we show that high-frequency DBS induced 1:2 gamma entrainment in 15/19 patients. Spontaneous FTG was present in 8 patients; in five of these patients dyskinesia occurred or were enhanced with entrained gamma activity during stimulation. Further, there was a significant increase in the power of 1:2 entrained gamma activity during movement in comparison to rest, while patients with entrainment had faster movements compared to those without. These findings argue for a functional relevance of the stimulation-induced 1:2 gamma entrainment in PD patients as a prokinetic activity that, however, is not necessarily promoting dyskinesia. DBS-induced entrainment can be a promising neurophysiological biomarker for identifying the optimal amplitude during closed-loop DBS.
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