ArticleTranslational psychiatry2025
Brain asymmetry and its association with inattention and heritability during neurodevelopment.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation.Nature communications · 2025Trial
- Attenuated rightward hemispheric asymmetry in ADHD: structural MRI evidence from a normalized asymmetry index and its association with cognitive performance.Frontiers in neuroscience · 2026Article
- Charting structural brain asymmetry across the human lifespan.bioRxiv : the preprint server for biology · 2025Article
- Comparative assessment of various protein isolates underpinning cognitive modulation: An interplay of neurobiological markers and gut-brain axis.Current research in food science · 2025Article
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2 authors.
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Abstract
The relationship between brain asymmetry and inattention, and their heritability is not well understood. Utilizing advanced neuroimaging, we examined brain asymmetry with data from the Adolescent Brain Cognitive Development (ABCD; n = 8943; 9-10 y) and the Human Connectome Project (HCP) cohorts (n = 1033; 5-100 y). Data-driven metrics from resting-state fMRI and morphometrics revealed reproducible and stable brain asymmetry patterns across the lifespan. In children, high levels of inattention were highly heritable (61%) and linked to reduced leftward asymmetry of functional connectivity in the dorsal posterior superior temporal sulcus (dpSTS), a region interconnected with a left-lateralized language network. However, reduced dpSTS asymmetry had low heritability (16%) and was associated with lower cognitive performance suggesting that non-genetic factors, such as those mediating cognitive performance, might underlie its association with dpSTS asymmetry. Interventions that enhance cognition might help optimize brain function and reduce inattention.
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