ArticleEJNMMI physics2025
Establishment of a practical methodology for evaluating equieffective dose of individual patients based on RT-PHITS.
Article in EJNMMI physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparative dosimetry study of PARaDIM and RT-PHITS with ICRP publication 128: calculation of organ doses fromRadiological physics and technology · 2026Article
- An analytical framework for efficient and precision-controlled Monte Carlo simulation of heterogeneous targeted alpha therapy microdosimetry.Medical physics · 2026Article
- Impact of simulation settings, time-activity curve integration range, and imaging time points on full Monte Carlo-basedAnnals of nuclear medicine · 2026Article
- Development of Linear Interpolation System for SMK Model Parameters Evaluated from Cellular-Scale Simulation (LISMEC) and its application to BNCT dosimetry.Journal of radiation research · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe RadioTherapy package based on PHITS (RT-PHITS) is an individual dosimetry system applicable to both targeted radionuclide therapy (TRT) and external radiotherapy. This study aims to establish a practical methodology for evaluating both absorbed doses and equieffective doses (EQDX) by improving RT-PHITS.
methodsWe developed an Excel-based program, ExPORT-PHITS, which simplifies the conversion of the dose rates of specific organs and tumors calculated by RT-PHITS into corresponding absorbed doses and EQDX. ExPORT-PHITS offers two options for evaluating EQDX, each adopting a different type of microdosimetric kinetic model, to assess its dependence. The performance of the improved RT-PHITS, including ExPORT-PHITS, was evaluated using SPECT/CT images of two castration-resistant prostate cancer patients with bone metastases after the injection of
resultsReasonable agreement was observed between absorbed doses calculated by RT-PHITS, IDAC Dose 2.1, and MIRDcalc, although absorbed doses in normal organs following the injection of
conclusionsThese findings underscore RT-PHITS as a valuable tool for accurately modeling and optimizing individual TRT, especially for treatments involving α-ray emitters.
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