Evidence map›Paper›PMID 40140219›Full record

ArticleTransgenic research2025

Plant-derived recombinant macromolecular PAP-IgG Fc as a novel prostate cancer vaccine candidate eliciting robust immune responses.

Yangjoo Kang, Deuk-Su Kim, Hyunjoo Hwang, Yerin Kim, Young-Jin Seo, Peter Hinterdorfer, Kisung Ko

Abstract read
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In one paragraph

Article in Transgenic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yangjoo KangDepartment of Medicine, Medicine of College, Chung-Ang University, Seoul, South Korea.
Deuk-Su KimDepartment of Medicine, Medicine of College, Chung-Ang University, Seoul, South Korea.
Hyunjoo HwangDepartment of Medicine, Medicine of College, Chung-Ang University, Seoul, South Korea.
Yerin KimDepartment of Medicine, Medicine of College, Chung-Ang University, Seoul, South Korea.
Young-Jin SeoDepartment of Life Science, Chung-Ang University, Seoul, South Korea.
Peter HinterdorferDepartment of Applied Experimental Biophysics, Johannes Kepler University Linz, 4040, Linz, Austria.
Kisung KoDepartment of Medicine, Medicine of College, Chung-Ang University, Seoul, South Korea. ksko@cau.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostatic acid phosphatase (PAP) is a specific protein that is highly expressed in prostate cancer. In this study, we constructed two recombinant PAP fusion genes: PAP fused to the immunoglobulin G (IgG) Fc fragment (designated PAP-Fc) and PAP-Fc fused to the endoplasmic reticulum retention sequence KDEL (designated PAP-FcK). Transgenic Nicotiana tabacum plants expressing these recombinant macromolecular proteins (MPs) were generated using Agrobacterium-mediated transformation, and the presence of both genes was confirmed through genomic PCR. Western blot analysis validated the expression of PAP-Fc and PAP-FcK MPs, which were successfully purified via protein A affinity chromatography. Size-exclusion high-performance liquid chromatography revealed dimeric peaks for PAP-Fc (PAP-Fc

Indexed as

Cancer VaccinesImmunoglobulin Fc FragmentsImmunoglobulin GProstatic NeoplasmsProtein Tyrosine PhosphatasesAcid PhosphataseAnimalsHumansMaleMiceNicotianaPlants, Genetically ModifiedRecombinant Fusion ProteinsAcid PhosphataseCancer VaccinesImmunoglobulin Fc FragmentsImmunoglobulin Gprostatic acid phosphataseProtein Tyrosine PhosphatasesRecombinant Fusion ProteinsProstate acid phosphataseProstate cancerProstate specific antigenTransgenic plantVaccine

Identifiers

PMID40140219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.