Evidence map›Paper›PMID 40140150›Full record

ReviewAnnals of biomedical engineering2025

Multifunctional Magnetic Nanoparticles for Targeted Drug Delivery Against Cancer: A Review of Mechanisms, Applications, Consequences, Limitations, and Tailoring Strategies.

Shumaila Riaz, Shaukat Ali, Muhammad Summer, Urva Akhtar, Shehzeen Noor, Rimsha Haqqi, Muhammad Adeel Farooq, Iqra Sardar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Spatiotemporal cancer controlNanomedicine (London, England) · 2026
    Review
  2. Size-Dependent Immunomodulatory Effects of FeMolecules (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Stimuli-Responsive Nanoplatforms for Precision Intervention in Rheumatoid Arthritis.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shumaila RiazMedical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan.
Shaukat AliMedical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan. dr.shaukatali@gcu.edu.pk.ORCID http://orcid.org/0000-0003-2481-1978
Muhammad SummerMedical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan.
Urva AkhtarMedical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan.
Shehzeen NoorMedical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan.
Rimsha HaqqiMedical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan.
Muhammad Adeel FarooqMedical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan.
Iqra SardarMedical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic nanoparticles (MNPs) have revolutionized cancer therapy by serving as effective drug transporters through active and passive targeting of tumor sites in conjugation with external alternating magnetic fields (AMFs), thus minimizing off-target effects. This precise targeting strategy guarantees a focused and controlled drug release at the tumor site, reducing the drawbacks of standard drug delivery systems and enhancing treatment effectiveness. Magnetic nanoparticles usually follow in magnetic hyperthermia (MHT) therapy, where AMFs raise the temperature at the tumor site, efficiently eliminating cancer cells and presenting a hopeful complement to conventional cancer treatments. In addition, side effects are reduced by launching a smart drug delivery system (SDDSs) in which treatment efficacy is enhanced by reducing the dosage frequency. Intrinsic properties of MNPs are measured when they serve as contrast agents in magnetic resonance imaging (MRI), providing a diagnostic aspect to their therapeutic capabilities and enabling medical professionals to monitor and record treatment outcomes with precision and higher accuracy. This comprehensive review highlights the multifaceted potential of MNPs in reshaping cancer treatment, emphasizing their role in targeted drug delivery, hyperthermia therapy, and imaging applications, and underscoring their transformative impact on the future of oncological care.

Indexed as

Antineoplastic AgentsDrug Delivery SystemsMagnetite NanoparticlesMultifunctional NanoparticlesNeoplasmsAnimalsHumansHyperthermia, InducedMagnetic Resonance ImagingAntineoplastic AgentsMagnetite NanoparticlesCancer therapyEnhanced permeability and retention effectHyperthermiaSmart magnetic nanoparticlesTargeted drug delivery

Identifiers

PMID40140150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.