Evidence map›Paper›PMID 40140131›Full record

ArticleBulletin of experimental biology and medicine2025

Effect of Human Macrophage Conditioned Media on TGF-β-Induced Differentiation of Lung Fibroblasts.

A A Maksimova, E Ya Shevela, M A Tikhonova, I M Rashchupkin, A A Ostanin, E R Chernykh

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A A MaksimovaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia. parkinson.dses@gmail.com.
E Ya ShevelaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
M A TikhonovaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
I M RashchupkinResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
A A OstaninResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
E R ChernykhResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the ability of human macrophage conditioned media to inhibit differentiation of lung fibroblasts in vitro. The results showed that the conditioned medium of M-CSF-differentiated non-polarized macrophages (induced by macrophage CSF) suppressed TGF-β-induced differentiation, reduced the expression of myofibroblast markers (α-smooth muscle actin and vimentin), and decreased the contractile activity of lung myofibroblasts, while the conditioned media of dexamethasone-polarized macrophages and GM-CSF-differentiated non-polarized macrophages (differentiation stimulus is granulocyte-macrophage CSF) produced no such effects. Thus, the obtained data indicate the antifibrogenic potential of non-polarized M-CSF-differentiated macrophages.

Indexed as

Cell DifferentiationFibroblastsLungMacrophagesTransforming Growth Factor betaActinsCells, CulturedCulture Media, ConditionedGranulocyte-Macrophage Colony-Stimulating FactorHumansMacrophage Colony-Stimulating FactorMyofibroblastsVimentinActinsCulture Media, ConditionedGranulocyte-Macrophage Colony-Stimulating FactorMacrophage Colony-Stimulating FactorTransforming Growth Factor betaVimentinconditioned mediumdifferentiationhuman macrophageslung fibroblastspolarization

Identifiers

PMID40140131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.