Evidence map›Paper›PMID 40140089›Full record

ReviewVirchows Archiv : an international journal of pathology2025

The impact of histopathology on prognosis of squamous cell carcinoma of the larynx: can we do better?

Nina Zidar, Lester D R Thompson, Abbas Agaimy, Göran Stenman, Henrik Hellquist, Alfons Nadal, Antti A Mäkitie, Fernando López, Primož Strojan, Alfio Ferlito

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. "Histologic type, treatment and prognosis of carcinomas of the larynx: A review".Virchows Archiv : an international journal of pathology · 2026
    Review
  3. The histopathological spectrum of laryngeal epithelial neoplasia.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Nina ZidarFaculty of Medicine, Institute of Pathology, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia. nina.zidar@mf.uni-lj.si.ORCID http://orcid.org/0000-0001-6866-3220
Lester D R ThompsonHead and Neck Pathology Consultations, Woodlands Hills, CA, USA.
Abbas AgaimyComprehensive Cancer Center (CCC) Erlangen-EMN, Institute of Pathology, University Hospital, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Göran StenmanDepartment of Pathology, Sahlgrenska Center for Cancer Research, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
Henrik HellquistDepartment of Biomedical Sciences and Medicine, ABC-RI, University of Algarve, Faro, Portugal.
Alfons NadalDepartment of Pathology, Hospital Clinic, Barcelona, Spain.
Antti A MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, Research Program in Systems Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Fernando LópezDepartment of Otolaryngology, ISPA, IUOPA, CIBERONC, Hospital Universitario Central de Asturias, University of Oviedo, Oviedo, Spain.
Primož StrojanDepartment of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
Alfio FerlitoUniversity of Udine School of Medicine, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite decades of progress, laryngeal squamous cell carcinoma (SCC) is still associated with significant morbidity and mortality worldwide. Additional biomarkers are needed to apply precision medicine and predict the clinical course. We reviewed and summarised routinely reported histopathologic features (e.g. subtypes of laryngeal SCC) along with promising potential biomarkers not yet routinely assessed using international guidelines. These include extra- vs intratumoural vascular and perineural invasion, tumour budding, depth of invasion, and tumour-infiltrating lymphocytes. We also address the problem of specimen quality and type (open approach vs endoscopic surgery) and the related limitations. High-risk human papillomavirus infection is another controversial issue to be discussed, being rare in laryngeal SCC, with an indeterminate prognostic significance and less reliable p16 overexpression as a surrogate marker of HPV infection. Further studies are warranted to address the applicability and to see which of the described parameters may help to better stratify patients with laryngeal SCC and should therefore be included in the pathology report.

Indexed as

Carcinoma, Squamous CellLaryngeal NeoplasmsSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorHumansPapillomavirus InfectionsPrognosisBiomarkers, TumorBiomarkersDisease progressionHuman papillomavirusLarynxLymphocytes, Tumour-infiltratingMorbidityPrecision medicinePrognosisSquamous cell carcinoma

Identifiers

PMID40140089
PMCPMC12289838

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.