ReviewAnalytical chemistry2025
Violet Innovation Grade Index (VIGI): A New Survey-Based Metric for Evaluating Innovation in Analytical Methods.
Review in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Design-Assisted Chemometric UV Spectrophotometric Determination of Candesartan Cilexetil, Chlorthalidone and Amlodipine Using Principal Component Regression, Partial Least Squares and Genetic Algorithm-Partial Least Squares Models.Analytical science advances · 2026Article
- Eco-friendly method for the analysis of the soluble fraction of parabens leached from sludge of a hospital wastewater treatment plant-proof of concept.Analytical and bioanalytical chemistry · 2026Article
- Article
- Fourier-based chemometric resolution of the FOLFOX regimen through digital filtering with poly-metric sustainability assessment.Scientific reports · 2026Article
- Montmorillonite-fungal biomass hybrid as sustainable sorbent in rotating-disk sorptive extraction coupled to GC-MS for trace-level monitoring of estrogens in hospital wastewater.Analytical and bioanalytical chemistry · 2026Article
- AI-Driven Data Extraction and AGREE-Based Greenness Evaluation of Analytical Methods for Natural Products: Insights from Selected Studies.Analytical chemistry · 2026Article
- Sustainable miniaturized smartphone-coupled TLC platform for innovative cleaning validation: application to tizanidine combinations under challenging concentration ratios.Scientific reports · 2026Article
- Development of a capsule phase microextraction (CPME) protocol for the determination of four tetracyclines in human urine prior to HPLC-DAD analysis.Analytical and bioanalytical chemistry · 2026Article
- Sustainable high-throughput microwell spectrophotometric methods for avapritinib quality control via charge-transfer complexation.Scientific reports · 2026Article
- Article
- Sustainable multifaceted HPLC approach for concurrent quantitation of an octa-mixture used in upper respiratory therapy with a five-dimensional sustainability assessment.Scientific reports · 2026Article
- Article
- Article
- Sustainable chromatographic assays of a novel antifungal combination for keratomycosis.BMC chemistry · 2026Article
- Artificial intelligence versus traditional approaches in multicomponent spectral analysis.Scientific reports · 2026Article
- Environmentally sustainable UV spectrophotometric-chemometric approach for simultaneous determination of budesonide, glycopyrrolate, and formoterol.BMC chemistry · 2026Article
- Evaluation of six eco-analytical tools for the sustainable HPLC analysis of a quinary anti-cold drug mixture.Scientific reports · 2026Article
- Eco-Friendly Sample Preparation Trends for Exogenous Toxic Organic Compounds in Food: A Sustainable Perspective for LC-MS Analysis.Foods (Basel, Switzerland) · 2026Review
- Article
- Breakthrough RP-HPLC strategy for synchronous analysis of pyridine and its degradation products in powder for injection using quality metrics.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The violet innovation grade index (VIGI) is a pioneering metric designed to evaluate the degree of innovation in analytical methods. This study introduces the VIGI tool (https://bit.ly/VIGItool) and demonstrates its application in assessing the innovative potential of various analytical techniques. VIGI integrates ten distinct criteria─sample preparation and instrumentation, data processing and software, white analytical chemistry and its derivatives, regulatory compliance, materials and reagents, miniaturization, automation, interdisciplinarity, sensitivity, and approach─providing a comprehensive evaluation that complements existing green, blue, and red metrics. Each method is assessed using a survey-based approach, resulting in a star-shaped decagon pictogram that visually represents its innovation score. The VIGI metric was successfully applied to five case studies, revealing insights into the strengths and weaknesses of each method in terms of innovation. Methods incorporating advanced materials, miniaturized devices, and automation scored highly, reflecting their cutting-edge contributions to analytical chemistry. Conversely, methods lacking advanced data processing or interdisciplinary applications scored lower, highlighting areas for potential improvement. This work underscores the importance of prioritizing innovative metrics like VIGI in the development and evaluation of analytical methods to ensure that analytical chemistry remains at the forefront of scientific advancement through more effective and sustainable practices.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.