SynthesisAJNR. American journal of neuroradiology2025
Long-Term (12 Months) Outcomes of Endovascular Thrombectomy for Large Core Stroke: A Meta-Analysis of SELECT2, TESLA, TENSION, and LASTE Trials.
Synthesis in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Endovascular thrombectomy for distal medium vessel occlusion stroke: A meta-analysis of randomized controlled trials.Neurosurgical review · 2025Pooled it
- Long-term outcomes of endovascular thrombectomy vs. medical care in patients with large ischemic stroke: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurologyPooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndovascular thrombectomy (EVT) has demonstrated benefits over standard medical care (MC) in randomized controlled trials (RCTs) for patients with large vessel occlusion (LVO) and large infarct territory at 90 days. However, conflicting evidence exists regarding long-term safety and efficacy of EVT in these populations. PURPOSE: To evaluate the clinical benefits of EVT in patients with large-core infarction through meta-analysis of high-quality RCT evidence with up to one-year follow-up. DATA SOURCES: PubMed/MEDLINE, Web of Science, and Scopus databases. STUDY SELECTION: RCTs involving patients with confirmed LVO and Alberta Stroke Program Early CT Score (Alberta Stroke Program Early CT Score [ASPECTS]) of ≤5, comparing EVT plus MC versus MC alone, with long-term outcome data. DATA ANALYSIS: Meta-analysis of long-term functional and safety outcomes with subgroup analysis comparing long-term (≤1 year) versus short-term (≤90 days) data on functional outcomes, imaging modalities, and presentation window. Leave-one-out sensitivity analysis was performed to resolve heterogeneity. DATA SYNTHESIS: Four RCTs comprising 1229 patients (49% female) were included. EVT demonstrated significant superiority over MC in functional independence (modified Rankin Scale [mRS] 0-2) (RR 3.91, 95% CI 2.7-5.66; LIMITATIONS: Study limited to RCT data with potential variations in thrombectomy techniques and patient selection criteria across trials.
conclusionsIn patients with ischemic stroke due to LVO with established large core infarct, EVT plus MC showed significant long-term benefits in functional outcomes, survival, and quality of life compared to MC alone.
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Registered trials
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