Evidence map›Paper›PMID 40139877›Full record

ArticleJACC. Basic to translational science2025

Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy.

Dipak Panigrahy, Abigail G Kelly, Katherine M Quinlivan, Weicang Wang, Jun Yang, Sung Hee Hwang, Michael Gillespie, Isabella V Howard, Carlos Bueno-Beti, Angeliki Asimaki and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Unraveling "Hot Phases" of Arrhythmogenic Cardiomyopathy.JACC. Basic to translational science · 2025
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Dipak PanigrahyDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Abigail G KellyDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Katherine M QuinlivanDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Weicang WangDepartment of Entomology and Nematology and UC-Davis Comprehensive Cancer Center, University of California, Davis, Calfornia, USA.
Jun YangDepartment of Entomology and Nematology and UC-Davis Comprehensive Cancer Center, University of California, Davis, Calfornia, USA.
Sung Hee HwangDepartment of Entomology and Nematology and UC-Davis Comprehensive Cancer Center, University of California, Davis, Calfornia, USA.
Michael GillespieDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Isabella V HowardDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Carlos Bueno-BetiCardiovascular and Genomics Research Institute, St. George's, University of London, London, United Kingdom.
Angeliki AsimakiCardiovascular and Genomics Research Institute, St. George's, University of London, London, United Kingdom.
Vinay PennaCardiovascular Division, Department of Medicine, Washington University, St. Louis, Missouri, USA.
Kory LavineCardiovascular Division, Department of Medicine, Washington University, St. Louis, Missouri, USA.
Matthew L EdinNational Institute of Environmental Health Science, Research Triangle Park, North Carolina, USA.
Darryl C ZeldinNational Institute of Environmental Health Science, Research Triangle Park, North Carolina, USA.
Bruce D HammockDepartment of Entomology and Nematology and UC-Davis Comprehensive Cancer Center, University of California, Davis, Calfornia, USA.
Jeffrey E SaffitzDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. Electronic address: jsaffitz@bidmc.harvard.edu.

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI YOUNG, THOMAS MICHAEL · 1987 to 2021
$50.1M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3M
NHLBI NIH HHS R35 HL161185NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R35 ES030443
6 · The paper itself

Abstract

We analyzed the role of pro- and anti-inflammatory eicosanoids in the pathogenesis of arrhythmogenic cardiomyopathy (ACM). Lipidomics revealed reduced levels of anti-inflammatory oxylipins in plasma and increased levels of pro-inflammatory eicosanoids in hearts of Dsg2

Indexed as

lipidomicsoxylipinspro-inflammatory eicosanoids

Identifiers

PMID40139877
PMCPMC12013847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.