ArticleFukushima journal of medical science2025
Serum low density lipoprotein cholesterol / high density lipoprotein cholesterol ratio predicts lower urinary tract dysfunction related dyslipidemia.
Article in Fukushima journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the effect of dyslipidemia on the lower urinary tract function by examining the LDL-C/HDL-C ratio in patients without bladder outlet obstruction (BOO).
methodsPatients who underwent urodynamic study before robot-assisted radical prostatectomy were included. Exclusion criteria were diabetes mellitus (HbA1c > 6.2%) and BOO (Schäfer nomogram obstruction III - V). The association between the preoperative LDL-C/HDL-C ratio and urodynamic findings were analyzed. Patients were divided into two groups based on Schäfer nomogram: weak contraction group (W-, W+, N-) and strong contraction group (N+, ST) to assess the relationship between the LDL-C/HDL-C ratio and bladder contraction.
resultsA total of 52 patients entered the study. The LDL-C/HDL-C ratio was 2.4 ± 0.8. The preoperative international prostate symptom score was mild (6.7 ± 5.6). Voided volume was significantly positively associated with the LDL-C/HDL-C ratio (P=0.041). The LDL-C/HDL-C ratio was significantly less in the strong contraction group than in the weak contraction group (P=0.047). Receiver operating characteristic (ROC) analysis showed a cut-off value of 2.15 for the LDL-C/HDL-C ratio in predicting weak bladder contraction.
conclusionsDyslipidemia-induced lower urinary tract dysfunction (LUTD) showed less bladder contractility with larger voided volume. The LDL-C/HDL-C ratio ≥ 2.15 may be a useful marker of dyslipidemia-induced LUTD.
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