Evidence map›Paper›PMID 40139717›Full record

ArticleInterdisciplinary cardiovascular and thoracic surgery2025

Patients with coronavirus disease 2019 and spontaneous pneumothorax: a propensity-matched, multicentre case-control study.

Arianna Farronato, Chiara Travaglia, Alice Ravasin, Vittorio Aprile, Roberto Corzani, Elisa Sicolo, Adriano Peris, Stefano Romagnoli, Marco Lucchi, Piero Paladini and 2 more

Abstract readMulticenter Study
In one paragraph

Article in Interdisciplinary cardiovascular and thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arianna FarronatoThoracic Surgery Unit, Department of Experimental and Clinical Medicine, University Hospital of Florence Careggi, Florence, Italy.ORCID 0009-0004-5630-2160
Chiara TravagliaDepartment of Health Science, Section of Anaesthesia and Intensive Care, University Hospital of Florence Careggi, Florence, Italy.
Alice RavasinThoracic Surgery Unit, Department of Experimental and Clinical Medicine, University Hospital of Florence Careggi, Florence, Italy.
Vittorio AprileDivision of Thoracic Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University Hospital of Pisa, Pisa, Italy.ORCID 0000-0001-8538-1719
Roberto CorzaniThoracic Surgery Unit, Department of Medical, Surgical and Neuroscience Sciences, University Hospital of Siena, 53100 Siena, Italy.
Elisa SicoloDivision of Thoracic Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University Hospital of Pisa, Pisa, Italy.
Adriano PerisIntensive Care Unit and Regional ECMO Referral Centre, Section of Anaesthesia and Intensive Care, University Hospital of Florence, Careggi, Florence, Italy.
Stefano RomagnoliDepartment of Health Science, Section of Anaesthesia and Intensive Care, University Hospital of Florence Careggi, Florence, Italy.
Marco LucchiDivision of Thoracic Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University Hospital of Pisa, Pisa, Italy.ORCID 0000-0001-9909-6820
Piero PaladiniThoracic Surgery Unit, Department of Medical, Surgical and Neuroscience Sciences, University Hospital of Siena, 53100 Siena, Italy.
Luca VoltoliniThoracic Surgery Unit, Department of Experimental and Clinical Medicine, University Hospital of Florence Careggi, Florence, Italy.
Alessandro GonfiottiThoracic Surgery Unit, Department of Experimental and Clinical Medicine, University Hospital of Florence Careggi, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPneumothorax and pneumomediastinum have been frequently reported in coronavirus disease-19 (COVID-19), thus complicating the patient's overall health-care management and survival rate. The goal of this study was to evaluate the outcomes of patients with COVID-19 who developed spontaneous pneumothorax (SPN) or spontaneous pneumomediastinum (SPM).

methodsIn this Italian multicentre retrospective cohort study, medical records of non-vaccinated COVID-19 patients, from March 2020 to May 2021, were analysed. To reduce the risk of bias due to unbalanced groups, a propensity score matching approach was applied using logistic regression to estimate propensity scores. Separate multivariable generalized linear models were then used to assess the risk of in-hospital death and other outcomes.

resultsA total of 474 patients were assessed, 72 of whom developed SPN or SPM. In separate multivariable generalized linear model regression analyses of the unmatched cohort, SPN [odds ratio (OR) 2.44, 95% confidence interval (CI) 1.7-5.55; P = 0.031] was associated with an increase in the in-hospital death rate, results confirmed even after matching the 2 cohorts. SPM (OR 1.21, 95% CI 1.13-1.30, P < 0.001) and SPN (OR 1.34, 95% CI 1.26-1.43, P < 0.001) were associated with an increase in the length of hospital stay. The risk of in-hospital death also increased with age, comorbidities (classified by the Charlson comorbidity index) and smoking habits.

conclusionsSPN in hospitalized COVID-19 patients may be associated with an increased risk of in-hospital death and prolonged hospitalization.

Indexed as

COVID-19Mediastinal EmphysemaPneumothoraxAdultAgedCase-Control StudiesFemaleHospital MortalityHumansItalyMaleMiddle AgedPropensity ScoreRetrospective StudiesRisk FactorsSARS-CoV-2ARDSCoronavirusCOVID-19SARS-CoV-2Spontaneous pneumomediastinumSpontaneous pneumothorax

Identifiers

PMID40139717
PMCPMC12055755

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.