Evidence map›Paper›PMID 40139656›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Directional sensitivity analysis of the cerebral pressure-flow relationship during normothermia and moderate hyperthermia.

Mahmoudreza Taghizadeh, R Matthew Brothers, Lawrence Labrecque, Marc-Antoine Roy, Daniel Gagnon, Jonathan D Smirl, Craig G Crandall, Patrice Brassard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cerebrovascular regulation during heat stress.Experimental physiology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Mahmoudreza TaghizadehDepartment of Kinesiology, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada.
R Matthew BrothersDepartment of Kinesiology, The University of Texas at Arlington, Arlington, Texas, United States.ORCID 0000-0002-3281-5277
Lawrence LabrecqueDepartment of Kinesiology, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada.ORCID 0000-0001-5440-2804
Marc-Antoine RoyDepartment of Kinesiology, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada.ORCID 0000-0002-2300-7403
Daniel GagnonSchool of Kinesiology and Exercise Science, Université de Montreal, Montreal, Quebec, Canada.ORCID 0000-0001-5396-9489
Jonathan D SmirlCerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
Craig G CrandallInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0001-7792-9713
Patrice BrassardDepartment of Kinesiology, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada.ORCID 0000-0002-6254-5044

Funding

Heat waves and the elderly: reducing thermal and cardiovascular consequencesR01AG069005 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 2021 to 2025
$2.8M
HYPERTHERMIA EFFECTS ON HUMAN BAROFLEX FUNCTIONR01HL061388 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 1999 to 2011
$2.4M
Neural and non-neural modulators of skin blood flow and sweating in humansR01HL084072 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 2006 to 2009
$1.3M
Blood Institute GrantsHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL-611388HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL-84072NHLBI NIH HHS R01 HL061388NHLBI NIH HHS R01 HL084072NIA NIH HHS R01 AG069005Research and Education Institute of Texas Health Resources
6 · The paper itself

Abstract

Dynamic cerebral autoregulation (dCA) reacts differently when mean arterial pressure (MAP) increases versus decreases (i.e., directional sensitivity). Although heat stress alters dCA, its influence on directional sensitivity remains unclear. This analysis investigated the impact of moderate hyperthermia on the directional sensitivity in the cerebral pressure-flow relationship. Ten healthy participants (7 males; age: 37 ± 12 yr; body mass: 75 ± 9 kg) underwent 6 min of oscillatory lower body negative pressure (OLBNP) to induce large MAP fluctuations at 0.03 and 0.10 Hz under normothermic and moderately hyperthermic conditions (+1.0°C increase in core temperature) induced via a water-perfused suit. We calculated changes in middle cerebral artery mean blood velocity (MCAv) per alterations to MAP to compute absolute and relative ratios adjusted for time intervals during each OLBNP-induced MAP increase (ΔMCAv

Indexed as

Cerebrovascular CirculationFeverHyperthermiaIntracranial PressureAdultArterial PressureBlood Flow VelocityBlood PressureBody TemperatureFemaleHomeostasisHumansLower Body Negative PressureMaleMiddle AgedMiddle Cerebral Arterydirectional sensitivitydynamic cerebral autoregulationheat stressmiddle cerebral arteryoscillatory lower body negative pressure

Identifiers

PMID40139656
PMCPMC12128508

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.