ArticleOsteoarthritis and cartilage2025
Effects of kinematic and kinetic variables on articular cartilage mechanical and biological properties.
Article in Osteoarthritis and cartilage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Dynamic Mechanics and Longitudinal Changes in Temporomandibular Joint Structural Integrity.Journal of oral rehabilitation · 2026Article
- Article
- Long-term mechanical loading aggravates osteoarthritis through a pro-apoptotic inflammatory microenvironment.Journal of biomedical research · 2026Article
- Clinical Efficacy of Acupuncture for Knee Osteoarthritis and Associated Changes in Serum Lipidomics: A Prospective Observational Cohort Study.Journal of pain research · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveDuring daily activity, the knee joint experiences a range of complex joint motion and loading patterns. However, few studies have investigated the effects of combined motion and load to understand how interactions between these factors may affect articular hyaline cartilage at the tissue and cell level. Our objective was to quantify the effects of varying combinations of physiologically relevant analogs of specific knee movements and loading on cartilage mechanical and biological properties.
designUsing response surface methodology applied to an established bioreactor-indenter workflow, we quantified the effect of load (20-60N, or ∼1-3 MPa), sliding speed (1-100 mm/s) and migrating contact frequency (0.00-0.2 Hertz) on changes in cartilage stiffening ratio, cartilage deformation (i.e., surface height displacement), cell viability, histopathological score, and gene expression. All kinetic and kinematic input ranges were chosen to fall within established physiological ranges in the knee. Bioreactor testing was conducted using a ceramic counterface and a testing lubricant of culture medium.
resultsCartilage stiffening ratio increased after loading - the magnitude of the change was affected by load and sliding speed. Minimum cartilage deformation occurred at low load and high sliding speed. Superficial cell death was driven by an interaction of load and sliding speed, with the highest percentages of cell death at high loads. No terms were observed to have significant effects on histopathological score.
conclusionsOur findings provide a better understanding of how kinematic and kinetic factors modulate cartilage responses at the matrix and the cell level, by quantifying the cartilage response using physiological input parameters.
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Registered trials
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