Evidence map›Paper›PMID 40139526›Full record

ArticleJournal of advanced research2026

Inosine monophosphate overcomes the coexisting resistance of mcr-1 and bla

Liang Zhao, Jian Xu, Saiwa Liu, Jingjing Du, Xixi Jia, Zhinan Wang, Lirui Ge, Kexin Cui, Yu Ga, Xiaowei Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Matrine Restores Colistin Efficacy AgainstMolecules (Basel, Switzerland) · 2025
    Article
  5. Antimicrobial resistance ofFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liang ZhaoNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jian XuNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Saiwa LiuNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jingjing DuNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Xixi JiaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhinan WangNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Lirui GeNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Kexin CuiNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Yu GaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Xiaowei LiNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Xi XiaNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address: xxia@cau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe rise of antibiotic-resistant bacteria, particularly those harboring mcr-1 and bla

objectivesThis study aims to investigate the impact of mcr-1 and bla

methodsWe employed non-targeted metabolomics to profile the metabolic perturbations of E. coli strains harboring mcr-1 and bla

resultsMetabolic profiling revealed significant alterations in the purine pathway, with IMP demonstrating potent bactericidal activity against E. coli strains carrying both resistance genes. IMP increased membrane permeability, disrupted proton motive force, reduced ATP levels, induced oxidative damage by promoting reactive oxygen species and inhibiting bacterial antioxidant defenses, and improved the survival rate of infected mice.

conclusionOur findings suggest that IMP could be a promising candidate for combating mcr-1 and bla

Indexed as

beta-LactamasesDrug Resistance, BacterialDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli ProteinsInosine MonophosphateAnimalsAnti-Bacterial AgentsColistinEscherichia coli InfectionsMiceMicrobial Sensitivity TestsAnti-Bacterial Agentsbeta-lactamase NDM-1beta-LactamasesColistinEscherichia coli ProteinsInosine MonophosphateMCR-1 protein, E coliAntibacterial agentBla(NDM-1)Inosine monophosphateMcr-1

Identifiers

PMID40139526
PMCPMC12766178

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.